Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

[HTML][HTML] Oxidative eustress: On constant alert for redox homeostasis

H Sies - Redox Biology, 2021 - Elsevier
In the open metabolic system, redox-related signaling requires continuous monitoring and
fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a …

Manmade electromagnetic fields and oxidative stress—biological effects and consequences for health

D Schuermann, M Mevissen - International journal of molecular sciences, 2021 - mdpi.com
Concomitant with the ever-expanding use of electrical appliances and mobile
communication systems, public and occupational exposure to electromagnetic fields (EMF) …

The interplay between intracellular iron homeostasis and neuroinflammation in neurodegenerative diseases

J Lee, DH Hyun - Antioxidants, 2023 - mdpi.com
Iron is essential for life. Many enzymes require iron for appropriate function. However,
dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species …

Connecting the “dots”: from free radical lipid autoxidation to cell pathology and disease

MK Foret, R Lincoln, S Do Carmo, AC Cuello… - Chemical …, 2020 - ACS Publications
Our understanding of lipid peroxidation in biology and medicine is rapidly evolving, as it is
increasingly implicated in various diseases but also recognized as a key part of normal cell …

Targeting oxidative stress involved in endometriosis and its pain

L Clower, T Fleshman, WJ Geldenhuys, N Santanam - Biomolecules, 2022 - mdpi.com
Endometriosis is a common gynecological disorder seen in women and is characterized by
chronic pelvic pain and infertility. This disorder is becoming more prevalent with increased …

Artesunate inhibits the cell growth in colorectal cancer by promoting ROS-dependent cell senescence and autophagy

Z Huang, S Gan, X Zhuang, Y Chen, L Lu, Y Wang… - Cells, 2022 - mdpi.com
Although artesunate has been reported to be a promising candidate for colorectal cancer
(CRC) treatment, the underlying mechanisms and molecular targets of artesunate are yet to …

Reactive oxygen species: angels and demons in the life of a neuron

K Biswas, K Alexander, MM Francis - NeuroSci, 2022 - mdpi.com
Reactive oxygen species (ROS) have emerged as regulators of key processes supporting
neuronal growth, function, and plasticity across lifespan. At normal physiological levels, ROS …

[HTML][HTML] Nox4 as a novel therapeutic target for diabetic vascular complications

D Wang, J Li, G Luo, J Zhou, N Wang, S Wang, R Zhao… - Redox Biology, 2023 - Elsevier
Diabetic vascular complications can affect both microvascular and macrovascular. Diabetic
microvascular complications, such as diabetic nephropathy, diabetic retinopathy, diabetic …

Endoplasmic reticulum-mitochondria contacts modulate reactive oxygen species-mediated signaling and oxidative stress in brain disorders: The key role of sigma-1 …

R Resende, T Fernandes, AC Pereira… - Antioxidants & Redox …, 2022 - liebertpub.com
Significance: Mitochondria-Associated Membranes (MAMs) are highly dynamic endoplasmic
reticulum (ER)-mitochondria contact sites that, due to the transfer of lipids and Ca2+ …