Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options
Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …
[HTML][HTML] The pharmacology and clinical efficacy of antiseizure medications: from bromide salts to cenobamate and beyond
Epilepsy is one of the most common and disabling chronic neurological disorders.
Antiseizure medications (ASMs), previously referred to as anticonvulsant or antiepileptic …
Antiseizure medications (ASMs), previously referred to as anticonvulsant or antiepileptic …
Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs: a 30-year longitudinal cohort study
Importance A study published in 2000 showed that more than one-third of adults with
epilepsy have inadequate control of seizures with antiepileptic drugs (AEDs). This study …
epilepsy have inadequate control of seizures with antiepileptic drugs (AEDs). This study …
[HTML][HTML] Drug-resistant epilepsy: multiple hypotheses, few answers
Epilepsy is a common neurological disorder that affects over 70 million people worldwide.
Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients …
Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients …
Astrocytes: a central element in neurological diseases
The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …
primary component in the pathogenesis of neurological diseases. As this concept is …
Animal models of seizures and epilepsy: past, present, and future role for the discovery of antiseizure drugs
W Löscher - Neurochemical research, 2017 - Springer
The identification of potential therapeutic agents for the treatment of epilepsy requires the
use of seizure models. Except for some early treatments, including bromides and …
use of seizure models. Except for some early treatments, including bromides and …
Patterns of treatment response in newly diagnosed epilepsy
Objective: To delineate the temporal patterns of outcome and to determine the probability of
seizure freedom with successive antiepileptic drug regimens in newly diagnosed epilepsy …
seizure freedom with successive antiepileptic drug regimens in newly diagnosed epilepsy …
New avenues for anti-epileptic drug discovery and development
W Löscher, H Klitgaard, RE Twyman… - Nature reviews drug …, 2013 - nature.com
Despite the introduction of over 15 third-generation anti-epileptic drugs, current medications
fail to control seizures in 20–30% of patients. However, our understanding of the …
fail to control seizures in 20–30% of patients. However, our understanding of the …
[HTML][HTML] Structural, molecular, and functional alterations of the blood-brain barrier during epileptogenesis and epilepsy: a cause, consequence, or both?
W Löscher, A Friedman - International journal of molecular sciences, 2020 - mdpi.com
The blood-brain barrier (BBB) is a dynamic, highly selective barrier primarily formed by
endothelial cells connected by tight junctions that separate the circulating blood from the …
endothelial cells connected by tight junctions that separate the circulating blood from the …