[HTML][HTML] Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution
The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC)
mutational signature has only recently been detected in a multitude of cancers through next …
mutational signature has only recently been detected in a multitude of cancers through next …
Human APOBEC3 variations and viral infection
S Sadeghpour, S Khodaee, M Rahnama, H Rahimi… - Viruses, 2021 - mdpi.com
Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
[HTML][HTML] SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is increased by a naturally occurring elongation variant
Y Konno, I Kimura, K Uriu, M Fukushi, T Irie… - Cell reports, 2020 - cell.com
One of the features distinguishing SARS-CoV-2 from its more pathogenic counterpart SARS-
CoV is the presence of premature stop codons in its ORF3b gene. Here, we show that SARS …
CoV is the presence of premature stop codons in its ORF3b gene. Here, we show that SARS …
Sarbecovirus ORF6 proteins hamper induction of interferon signaling
I Kimura, Y Konno, K Uriu, K Hopfensperger, D Sauter… - Cell reports, 2021 - cell.com
The presence of an ORF6 gene distinguishes sarbecoviruses such as severe acute
respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other …
respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other …
N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation
D Yamasoba, K Sato, T Ichinose, T Imamura… - Nature …, 2019 - nature.com
RNA-modulating factors not only regulate multiple steps of cellular RNA metabolism, but
also emerge as key effectors of the immune response against invading viral pathogens …
also emerge as key effectors of the immune response against invading viral pathogens …
APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1
ABSTRACT HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4+
T lymphocytes and macrophages. Previous studies have demonstrated that the …
T lymphocytes and macrophages. Previous studies have demonstrated that the …
Type I interferon responses by HIV-1 infection: association with disease progression and control
A Soper, I Kimura, S Nagaoka, Y Konno… - Frontiers in …, 2018 - frontiersin.org
Human immunodeficiency virus type 1 (HIV-1) is the causative agent of acquired
immunodeficiency syndrome and its infection leads to the onset of several disorders such as …
immunodeficiency syndrome and its infection leads to the onset of several disorders such as …
The battle between retroviruses and APOBEC3 genes: its past and present
The APOBEC3 family of proteins in mammals consists of cellular cytosine deaminases and
well-known restriction factors against retroviruses, including lentiviruses. APOBEC3 genes …
well-known restriction factors against retroviruses, including lentiviruses. APOBEC3 genes …
The antiviral and cancer genomic DNA deaminase APOBEC3H is regulated by an RNA-mediated dimerization mechanism
NM Shaban, K Shi, KV Lauer, MA Carpenter… - Molecular cell, 2018 - cell.com
Human APOBEC3H and homologous single-stranded DNA cytosine deaminases are
unique to mammals. These DNA-editing enzymes function in innate immunity by restricting …
unique to mammals. These DNA-editing enzymes function in innate immunity by restricting …
The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function
T Yamaguchi, T Suzuki, T Sato, A Takahashi… - Science …, 2018 - science.org
Shortening and removal of the polyadenylate [poly (A)] tail of mRNA, a process called
deadenylation, is a key step in mRNA decay that is mediated through the CCR4-NOT …
deadenylation, is a key step in mRNA decay that is mediated through the CCR4-NOT …