Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets

V Micale, M Di Bartolomeo, S Di Martino, T Stark… - Pharmacology & …, 2023 - Elsevier
The etiopathogenesis of mental disorders is not fully understood and accumulating evidence
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …

Epigenetic targets in schizophrenia development and therapy

A Wawrzczak-Bargieła, W Bilecki, M Maćkowiak - Brain Sciences, 2023 - mdpi.com
Schizophrenia is regarded as a neurodevelopmental disorder with its course progressing
throughout life. However, the aetiology and development of schizophrenia are still under …

Exosomal secretion of a psychosis-altered miRNA that regulates glutamate receptor expression is affected by antipsychotics

SK Amoah, BA Rodriguez, CN Logothetis… - …, 2020 - nature.com
The ability of small secretory microvesicles known as exosomes to influence neuronal and
glial function via their microRNA (miRNA) cargo has positioned them as a novel and …

Micro spies from the brain to the periphery: new clues from studies on microRNAs in neuropsychiatric disorders

E Maffioletti, D Tardito, M Gennarelli… - Frontiers in cellular …, 2014 - frontiersin.org
microRNAs (miRNAs) are small non-coding RNAs (20–22 nucleotides) playing a major role
in post-transcriptional regulation of gene expression. miRNAs are predicted to regulate more …

Etiology of cardiovascular disease in patients with schizophrenia: current perspectives

M Emul, T Kalelioglu - Neuropsychiatric Disease and Treatment, 2015 - Taylor & Francis
Cardiovascular morbidity and mortality are important problems among patients with
schizophrenia. A wide spectrum of reasons, ranging from genes to the environment, are held …

Non-coding RNA as novel players in the pathophysiology of schizophrenia

A Gibbons, M Udawela, B Dean - Non-coding RNA, 2018 - mdpi.com
Schizophrenia is associated with diverse changes in the brain's transcriptome and
proteome. Underlying these changes is the complex dysregulation of gene expression and …

Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: past, present, and future

B Alural, S Genc, SJ Haggarty - Progress in Neuro-Psychopharmacology …, 2017 - Elsevier
Neuropsychiatric disorders are common health problems affecting approximately 1% of the
population. Twin, adoption, and family studies have displayed a strong genetic component …

Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue

CY Lai, SY Lee, E Scarr, YH Yu, YT Lin, CM Liu… - Translational …, 2016 - nature.com
Based on our previous finding of a seven-miRNA (hsa-miR-34a, miR-449a, miR-564, miR-
432, miR-548d, miR-572 and miR-652) signature as a potential biomarker for schizophrenia …

An update on the epigenetics of psychotic diseases and autism

HM Abdolmaleky, JR Zhou, S Thiagalingam - Epigenomics, 2015 - Taylor & Francis
The examination of potential roles of epigenetic alterations in the pathogenesis of psychotic
diseases have become an essential alternative in recent years as genetic studies alone are …

[HTML][HTML] Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with …

IA Akkouh, T Hughes, VM Steen, JC Glover… - Brain, behavior, and …, 2021 - Elsevier
Despite the high heritability of schizophrenia (SCZ), details of its pathophysiology and
etiology are still unknown. Recent findings suggest that aberrant inflammatory regulation …