Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets
V Micale, M Di Bartolomeo, S Di Martino, T Stark… - Pharmacology & …, 2023 - Elsevier
The etiopathogenesis of mental disorders is not fully understood and accumulating evidence
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …
Epigenetic targets in schizophrenia development and therapy
A Wawrzczak-Bargieła, W Bilecki, M Maćkowiak - Brain Sciences, 2023 - mdpi.com
Schizophrenia is regarded as a neurodevelopmental disorder with its course progressing
throughout life. However, the aetiology and development of schizophrenia are still under …
throughout life. However, the aetiology and development of schizophrenia are still under …
Exosomal secretion of a psychosis-altered miRNA that regulates glutamate receptor expression is affected by antipsychotics
SK Amoah, BA Rodriguez, CN Logothetis… - …, 2020 - nature.com
The ability of small secretory microvesicles known as exosomes to influence neuronal and
glial function via their microRNA (miRNA) cargo has positioned them as a novel and …
glial function via their microRNA (miRNA) cargo has positioned them as a novel and …
Micro spies from the brain to the periphery: new clues from studies on microRNAs in neuropsychiatric disorders
E Maffioletti, D Tardito, M Gennarelli… - Frontiers in cellular …, 2014 - frontiersin.org
microRNAs (miRNAs) are small non-coding RNAs (20–22 nucleotides) playing a major role
in post-transcriptional regulation of gene expression. miRNAs are predicted to regulate more …
in post-transcriptional regulation of gene expression. miRNAs are predicted to regulate more …
Etiology of cardiovascular disease in patients with schizophrenia: current perspectives
M Emul, T Kalelioglu - Neuropsychiatric Disease and Treatment, 2015 - Taylor & Francis
Cardiovascular morbidity and mortality are important problems among patients with
schizophrenia. A wide spectrum of reasons, ranging from genes to the environment, are held …
schizophrenia. A wide spectrum of reasons, ranging from genes to the environment, are held …
Non-coding RNA as novel players in the pathophysiology of schizophrenia
Schizophrenia is associated with diverse changes in the brain's transcriptome and
proteome. Underlying these changes is the complex dysregulation of gene expression and …
proteome. Underlying these changes is the complex dysregulation of gene expression and …
Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: past, present, and future
Neuropsychiatric disorders are common health problems affecting approximately 1% of the
population. Twin, adoption, and family studies have displayed a strong genetic component …
population. Twin, adoption, and family studies have displayed a strong genetic component …
Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue
CY Lai, SY Lee, E Scarr, YH Yu, YT Lin, CM Liu… - Translational …, 2016 - nature.com
Based on our previous finding of a seven-miRNA (hsa-miR-34a, miR-449a, miR-564, miR-
432, miR-548d, miR-572 and miR-652) signature as a potential biomarker for schizophrenia …
432, miR-548d, miR-572 and miR-652) signature as a potential biomarker for schizophrenia …
An update on the epigenetics of psychotic diseases and autism
HM Abdolmaleky, JR Zhou, S Thiagalingam - Epigenomics, 2015 - Taylor & Francis
The examination of potential roles of epigenetic alterations in the pathogenesis of psychotic
diseases have become an essential alternative in recent years as genetic studies alone are …
diseases have become an essential alternative in recent years as genetic studies alone are …
[HTML][HTML] Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with …
Despite the high heritability of schizophrenia (SCZ), details of its pathophysiology and
etiology are still unknown. Recent findings suggest that aberrant inflammatory regulation …
etiology are still unknown. Recent findings suggest that aberrant inflammatory regulation …