Hyperbaric oxygen therapy (HBOT) consists of using of pure oxygen at increased pressure
(in general, 2–3 atmospheres) leading to augmented oxygen levels in the blood …

Mitochondria are fundamental for metabolic homeostasis in all multicellular eukaryotes. In
the nervous system, mitochondria-generated adenosine triphosphate (ATP) is required to …

Effective metabolism is highly dependent on a narrow therapeutic range of oxygen.
Accordingly, low levels of oxygen, or hypoxia, are one of the most powerful inducers of gene …

Mitochondria are complex intracellular organelles traditionally identified as the
powerhouses of eukaryotic cells due to their central role in bioenergetic metabolism. In …

Mammalian genes were long thought to be constrained within somatic cells in most cell
types. This concept was challenged recently when cellular organelles including …

Neurons and glia maintain central nervous system (CNS) homeostasis through diverse
mechanisms of intra-and intercellular signaling. Some of these interactions include the …

Hyperbaric oxygen treatment (HBOT)—the medical use of oxygen at environmental pressure
greater than one atmosphere absolute—is a very effective therapy for several approved …

Intercellular mitochondria transfer is a novel form of cell signalling in which whole
mitochondria are transferred between cells in order to enhance cellular functions or aid in …

In the central nervous system (CNS), neuronal functionality is highly dependent on
mitochondrial integrity and activity. In the context of a damaged or diseased brain …

Abstract The World Health Organization estimates that by the year 2040, neurodegenerative
diseases will be the second leading cause of death in developed countries, overtaking …