Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …

Gonadotropins are glycoprotein sex hormones regulating development and reproduction
and bind to specific G protein–coupled receptors expressed in the gonads. Their effects on …

Follicle stimulating hormone (FSH) is an essential glycoprotein hormone for human
reproduction, which functions are mediated by a G protein-coupled receptor, FSHR …

Estrogen excess in females has been linked to a diverse array of chronic and acute
diseases. Emerging research shows that exposure to estrogen-like compounds such as …

Purpose The current clinical practice in reproductive medicine should pose the couple at the
centre of the diagnostic–therapeutic management of infertility and requires intense …

Knowledge on G protein-coupled receptor (GPCRs) structure and mechanism of activation
has profoundly evolved over the past years. The way drugs targeting this family of receptors …

Follicle‐stimulating hormone receptor (FSHR) is a class AG protein‐coupled receptor that
belongs to the subfamily of glycoprotein hormone receptors (GPHRs). The interaction of FSH …

Gonadotropins regulate reproductive functions by binding to G protein-coupled receptors
(FSHR and LHCGR) expressed in the gonads. They activate multiple, cell-specific signalling …

Introduction Infertility is recognized as a major global health issue, often associated with
significant psychological distress for affected couples. Causes of female infertility include …

Follicle-stimulating hormone receptor (FSHR) plays a key role in reproduction through the
activation of multiple signaling pathways. Low molecular weight (LMW) ligands composed of …