Differentiating between UCTD and early-stage SLE: from definitions to clinical approach

S Sciascia, D Roccatello, M Radin, I Parodis… - Nature Reviews …, 2022 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous clinical
manifestations that can potentially affect every organ and system. SLE is usually identified …

Very early systemic sclerosis

S Bellando-Randone, M Matucci-Cerinic - Best practice & research Clinical …, 2019 - Elsevier
The early diagnosis of systemic sclerosis (SSc) can be very difficult, when most of the typical
signs and symptoms are absent. For this reason, the approach to SSc has changed during …

[HTML][HTML] Predicting progression from undifferentiated connective tissue disease to definite connective tissue disease: a systematic review and meta-analysis

S Dyball, M Rodziewicz, C Mendoza-Pinto… - Autoimmunity …, 2022 - Elsevier
Purpose Undifferentiated connective tissue disease (UCTD) encapsulates a broad range of
conditions including incomplete forms of systemic lupus erythematosus (SLE) and systemic …

Very early systemic sclerosis and pre-systemic sclerosis: definition, recognition, clinical relevance and future directions

S Bellando-Randone, M Matucci-Cerinic - Current rheumatology reports, 2017 - Springer
Abstract Purpose of Review The approach to systemic sclerosis (SSc) has changed over the
years with an increasing focus on the very early diagnosis of the disease. The terminology …

Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated …

T Li, L Ortiz-Fernández, E Andrés-León, L Ciudad… - Genome medicine, 2020 - Springer
Abstract Background Systemic sclerosis (SSc) is a genetically complex autoimmune disease
mediated by the interplay between genetic and epigenetic factors in a multitude of immune …

Left ventricular diastolic dysfunction in systemic sclerosis: clinical, immunological and survival differences in the Spanish RESCLE registry

AG García, M Fabregate, L Manzano… - Seminars in Arthritis and …, 2022 - Elsevier
Objectives: Left ventricular diastolic dysfunction (LVDD) remains poorly studied in Systemic
Sclerosis (SSc). To determine the prevalence and to define factors associated with LVDD …

Resveratrol ameliorates systemic sclerosis via suppression of fibrosis and inflammation through activation of SIRT1/mTOR signaling

Q Yao, Q Wu, X Xu, Y Xing, J Liang, Q Lin… - Drug Design …, 2020 - Taylor & Francis
Purpose Resveratrol (Res) is a natural polyphenolic compound found in several plants and
reported as a promising biological molecule with effective anti-fibrosis and anti-inflammatory …

Undifferentiated connective tissue disease at risk for systemic sclerosis: which patients might be labeled prescleroderma?

G Valentini, JE Pope - Autoimmunity reviews, 2020 - Elsevier
Abstract Undifferentiated Connective Tissue Disease at risk for Systemic Sclerosis (UCTD-
risk-SSc), otherwise referred to as very early-early SSc (very early-early diagnosis of …

What have we learned on pre, very early, and early systemic sclerosis microcirculatory pathophysiology? A scoping review

J Caetano, LM Rodrigues, JD Alves - Autoimmunity Reviews, 2024 - Elsevier
Objective Microvascular dysfunction is an early event in the pathogenesis of systemic
sclerosis (SSc). The objective of this scoping review is to update the current information and …

Infrared thermography in children: a reliable tool for differential diagnosis of peripheral microvascular dysfunction and Raynaud's phenomenon?

G Martini, M Cappella, R Culpo, F Vittadello… - Pediatric …, 2019 - Springer
Abstract Background Infrared Thermography (IRT) has been used for over 30 years in the
assessment of Raynaud Phenomenon (RP) and other peripheral microvascular dysfunctions …