Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …

The primary progressive aphasias are a heterogeneous group of focal 'language-
led'dementias that pose substantial challenges for diagnosis and management. Here we …

The heterogeneity of neurodegenerative diseases is a key confound to disease
understanding and treatment development, as study cohorts typically include multiple …

Objective To characterize in vivo signatures of pathological diagnosis in a large cohort of
patients with primary progressive aphasia (PPA) variants defined by current diagnostic …

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

Accurately predicting the underlying neuropathological diagnosis in patients with
behavioural variant frontotemporal dementia (bvFTD) poses a daunting challenge for …

Frontotemporal dementia (FTD) is a neurodegenerative disease of growing interest, since it
accounts for up to 10% of middle-age-onset dementias and entails a social, economic, and …

Objective To estimate the prevalence of amyloid positivity, defined by positron emission
tomography (PET)/cerebrospinal fluid (CSF) biomarkers and/or neuropathological …

Frontotemporal dementia (FTD) is a clinically and pathologically heterogeneous group of
non-Alzheimer dementias characterised collectively by relatively selective, progressive …

Background: Frontotemporal dementia (FTD) describes a cluster of neurocognitive
syndromes that present with impairment of executive functioning, changes in behavior, and …