[HTML][HTML] Role of cholinergic signaling in Alzheimer's disease
ZR Chen, JB Huang, SL Yang, FF Hong - Molecules, 2022 - mdpi.com
Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal
transduction related to memory and learning ability. Alzheimer's disease (AD), a progressive …
transduction related to memory and learning ability. Alzheimer's disease (AD), a progressive …
β− Arrestins: structure, function, physiology, and pharmacological perspectives
The two β-arrestins, β-arrestin-1 and-2 (systematic names: arrestin-2 and-3, respectively),
are multifunctional intracellular proteins that regulate the activity of a very large number of …
are multifunctional intracellular proteins that regulate the activity of a very large number of …
[HTML][HTML] Cholinergic system and its therapeutic importance in inflammation and autoimmunity
N Halder, G Lal - Frontiers in immunology, 2021 - frontiersin.org
Neurological and immunological signals constitute an extensive regulatory network in our
body that maintains physiology and homeostasis. The cholinergic system plays a significant …
body that maintains physiology and homeostasis. The cholinergic system plays a significant …
[HTML][HTML] Muscarinic acetylcholine receptors for psychotic disorders: bench-side to clinic
Modern interest in muscarinic acetylcholine receptor (mAChR) activators for schizophrenia
began in the 1990s when xanomeline, an M 1/M 4-preferring mAChR agonist developed for …
began in the 1990s when xanomeline, an M 1/M 4-preferring mAChR agonist developed for …
[HTML][HTML] From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer's disease
AJH Brown, SJ Bradley, FH Marshall, GA Brown… - Cell, 2021 - cell.com
Current therapies for Alzheimer's disease seek to correct for defective cholinergic
transmission by preventing the breakdown of acetylcholine through inhibition of …
transmission by preventing the breakdown of acetylcholine through inhibition of …
Phosphorylation barcodes direct biased chemokine signaling at CXCR3
G protein-coupled receptor (GPCR)-biased agonism, selective activation of certain signaling
pathways relative to others, is thought to be directed by differential GPCR phosphorylation" …
pathways relative to others, is thought to be directed by differential GPCR phosphorylation" …
Targeting the M1 muscarinic acetylcholine receptor in Alzheimer's disease
Alzheimer's disease (AD) remains a major cause of morbidity and mortality worldwide, and
despite extensive research, only a few drugs are available for management of the disease …
despite extensive research, only a few drugs are available for management of the disease …
G protein–biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model
Y Huang, T Rafael Guimarães… - Proceedings of the …, 2022 - National Acad Sciences
Biased G protein–coupled receptor (GPCR) ligands, which preferentially activate G protein
or β-arrestin signaling pathways, are leading to the development of drugs with superior …
or β-arrestin signaling pathways, are leading to the development of drugs with superior …
[HTML][HTML] Fine tuning muscarinic acetylcholine receptor signaling through allostery and bias
The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug
targets for neurological diseases, in particular for Alzheimer's disease and schizophrenia …
targets for neurological diseases, in particular for Alzheimer's disease and schizophrenia …
[HTML][HTML] GPCRs in intracellular compartments: New targets for drug discovery
I Fasciani, M Carli, F Petragnano, F Colaianni, G Aloisi… - Biomolecules, 2022 - mdpi.com
The architecture of eukaryotic cells is defined by extensive membrane-delimited
compartments, which entails separate metabolic processes that would otherwise interfere …
compartments, which entails separate metabolic processes that would otherwise interfere …