Conventional chemotherapy, one of the most widely used cancer treatment methods, has
serious side effects, and usually results in cancer treatment failure. Drug resistance is one of …

This paper is the forty-fourth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Chronic pain is a growing public health crisis that requires exigent and efficacious
therapeutics. GPR171 is a promising therapeutic target that is widely expressed through the …

Genome-wide screens using yeast or phage displays are powerful tools for identifying
protein–ligand interactions, including drug or vaccine targets, ligand receptors, or protein …

Pain is the body's natural warning system to indicate one is in an environment highly
detrimental to survival. The body's response to the sensation of pain is to immediately …

Glioblastoma (GBM) is the deadliest primary brain tumour in adults with a median survival of
14-20 months from initial diagnosis. Despite aggressive treatment involving maximal …