Conclusion. Collectively, these studies suggest that endothelial dysfunction (1) is not unique
to chemically induced experimental models of IDDM,(2) is found in both conduit and …

Background Patients with heart failure have reduced peripheral blood flow at rest, during
exercise, and in response to endothelium-dependent vasodilators. Nitric oxide formed from l …

Blood flow in oral tissues, including the tongue, salivary glands, gingiva, dental pulp, and lip,
plays an important role in modulating the complex oral functions involved in food intake. Oral …

Arginine is a precursor amino acid for the synthesis of nitric oxide by nitric oxide synthase. A
defect in arginine supply could regulate nitric oxide-mediated, endothelium-dependent …

Provided are methods for preparing improved biologically active micelle and crystalline
products comprising a biologically active amphipathic compound in association with a …

A therapeutic mixture comprising a mixture of L-arginine and an agonist of nitric oxide
synthase, namely nitroglycerin, is disclosed for the treatment of diseases related to …

Objectives. This study sought to determine whether coronary endothelial dysfunction exists
in patients with acute-onset idiopathic dilated cardiomyopathy (DCM) and to explore its …

The present invention relates generally to biologically active compounds and more
specifically to compounds and peptides which are amphipathic, ie, have both hydrophilic …

It is commonly believed that the activity of NO synthase (NOS) solely controls NO production
from its substrates, l-Arg and O2. The Michaelis-Menten constant (K m) of NOS forl-Arg is in …

A therapeutic in vitro or in vivo mixture comprising L-arginine and an agonist of nitric oxide
synthase, namely nitroglycerin is disclosed for the treatment of diseases related to …