Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …

Members of the caspase family of proteases play essential roles in the initiation and
execution of apoptosis. These caspases are divided into two groups: the initiator caspases …

Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis,
which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still …

As much as the cellular viability is important for the living organisms, the elimination of
unnecessary or damaged cells has the opposite necessity for the maintenance of …

Adequate control of autoimmune diseases with an unclear etiology resulting from
autoreactivation of the immune system remains a major challenge. One of the factors that …

Apoptosis, or programmed cell death, plays a pivotal role in the elimination of unwanted,
damaged, or infected cells in multicellular organisms and also in diverse biological …

The process of programmed cell death, or apoptosis, is generally characterized by distinct
morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is …

Different types of cell death are often defined by morphological criteria, without a clear
reference to precise biochemical mechanisms. The Nomenclature Committee on Cell Death …

Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable
manner, as a result of their immediate structural breakdown. Such an unavoidable variant of …

Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed
by proteases called caspases. The Bcl2 family of intracellular proteins is the central …