[HTML][HTML] Research for new drugs for elimination of onchocerciasis in Africa
AC Kuesel - International Journal for Parasitology: Drugs and Drug …, 2016 - Elsevier
Onchocerciasis is a parasitic, vector borne disease caused by the filarial nematode
Onchocerca volvulus. More than 99% of the population at risk of infection live in Africa …
Onchocerca volvulus. More than 99% of the population at risk of infection live in Africa …
Onchocerciasis drug development: from preclinical models to humans
A Ngwewondo, I Scandale, S Specht - Parasitology Research, 2021 - Springer
Twenty diseases are recognized as neglected tropical diseases (NTDs) by World Health
Assembly resolutions, including human filarial diseases. The end of NTDs is embedded …
Assembly resolutions, including human filarial diseases. The end of NTDs is embedded …
Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity
SR Doyle, C Bourguinat… - PLoS neglected …, 2017 - journals.plos.org
Background Treatment of onchocerciasis using mass ivermectin administration has reduced
morbidity and transmission throughout Africa and Central/South America. Mass drug …
morbidity and transmission throughout Africa and Central/South America. Mass drug …
Effect of a single dose of 8 mg moxidectin or 150 μg/kg ivermectin on O. volvulus skin microfilariae in a randomized trial: Differences between areas in the …
D Bakajika, EM Kanza, NO Opoku… - PLoS Neglected …, 2022 - journals.plos.org
Background Our study in CDTI-naïve areas in Nord Kivu and Ituri (Democratic Republic of
the Congo, DRC), Lofa County (Liberia) and Nkwanta district (Ghana) showed that a single …
the Congo, DRC), Lofa County (Liberia) and Nkwanta district (Ghana) showed that a single …
Reproductive Status of Onchocerca volvulus after Ivermectin Treatment in an Ivermectin-Naïve and a Frequently Treated Population from Cameroon
HC Nana-Djeunga, C Bourguinat, SD Pion… - PLoS neglected …, 2014 - journals.plos.org
Background For two decades, onchocerciasis control has been based on mass treatment
with ivermectin (IVM), repeated annually or six-monthly. This drug kills Onchocerca volvulus …
with ivermectin (IVM), repeated annually or six-monthly. This drug kills Onchocerca volvulus …
Dynamics of Onchocerca volvulus Microfilarial Densities after Ivermectin Treatment in an Ivermectin-naïve and a Multiply Treated Population from Cameroon
SDS Pion, HC Nana-Djeunga, J Kamgno… - PLoS neglected …, 2013 - journals.plos.org
Background/Objective Ivermectin has been the keystone of onchocerciasis control for the
last 25 years. Sub-optimal responses to the drug have been reported in Ghanaian …
last 25 years. Sub-optimal responses to the drug have been reported in Ghanaian …
Prevalence and intensity of Loa loa infection over twenty-three years in three communities of the Mbalmayo health district (Central Cameroon)
AE Mogoung-Wafo, HC Nana-Djeunga… - BMC infectious …, 2019 - Springer
Background Loiasis is a vector-borne parasitic disease due to Loa loa and transmitted to
humans by tabanids of the genus Chrysops. Loiasis has been historically considered as the …
humans by tabanids of the genus Chrysops. Loiasis has been historically considered as the …
Single nucleotide polymorphisms in β-tubulin selected in Onchocerca volvulus following repeated ivermectin treatment: possible indication of resistance selection
H Nana-Djeunga, C Bourguinat, SDS Pion… - Molecular and …, 2012 - Elsevier
The control of onchocerciasis or river blindness by mass treatment of the population with
ivermectin (IVM) has been a great success until now, so that in certain foci its elimination has …
ivermectin (IVM) has been a great success until now, so that in certain foci its elimination has …
Ivermectin treatment response in Onchocerca volvulus infected persons with epilepsy: A three-country short cohort study
A Dusabimana, D Bhwana, S Raimon, BP Mmbando… - Pathogens, 2020 - mdpi.com
Despite a long history of community-directed treatment with ivermectin (CDTI), a high
ongoing Onchocerca volvulus transmission is observed in certain onchocerciasis-endemic …
ongoing Onchocerca volvulus transmission is observed in certain onchocerciasis-endemic …
Unusual Localization of Blood-Borne Loa loa Microfilariae in the Skin Depends on Microfilarial Density in the Blood: Implications for Onchocerciasis Diagnosis in …
Y Niamsi-Emalio, HC Nana-Djeunga… - Clinical Infectious …, 2021 - academic.oup.com
Background The diagnostic gold standard for onchocerciasis relies on identification and
enumeration of (skin-dwelling) Onchocerca volvulus microfilariae (mf) using the skin snip …
enumeration of (skin-dwelling) Onchocerca volvulus microfilariae (mf) using the skin snip …