[HTML][HTML] Flavonoids as alpha-glucosidase inhibitors: Mechanistic approaches merged with enzyme kinetics and molecular modelling

D Şöhretoğlu, S Sari - Phytochemistry Reviews, 2020 - Springer
Diabetes mellitus is a major, global public health problem. α-Glucosidase inhibitors are one
of the most widely used classes of oral antidiabetics. In addition to other pharmaceutical …

Application of carbohydrates in approved small molecule drugs: A review

H Jiang, X Qin, Q Wang, Q Xu, J Wang, Y Wu… - European Journal of …, 2021 - Elsevier
Carbohydrates are an important energy source and play numerous key roles in all living
organisms. Carbohydrates chemistry involved in diagnosis and treatment of diseases has …

Synthesis, crystal structure, DFT, α-glucosidase and α-amylase inhibition and molecular docking studies of (E)-N'-(4-chlorobenzylidene)-5-phenyl-1H-pyrazole-3 …

K Karrouchi, S Fettach, B Tüzün, S Radi… - Journal of Molecular …, 2021 - Elsevier
In this work, a novel crystal ie (E)-N'-(4-chlorobenzylidene)-5-phenyl-1H-pyrazole-3-
carbohydrazide has been synthesized and characterized using various spectroscopic …

[HTML][HTML] Comparison of Various Solvent Extracts and Major Bioactive Components from Portulaca oleracea for Antioxidant, Anti-Tyrosinase, and Anti-α-Glucosidase …

WC Chen, SW Wang, CW Li, HR Lin, CS Yang, YC Chu… - Antioxidants, 2022 - mdpi.com
Portulaca oleracea is a well-known species for traditional medicine and food homology in
Taiwan. In traditional medicine, P. oleracea is also used to treat gastrointestinal disorders …

[HTML][HTML] Antioxidant and Anti-α-Glucosidase Activities of Various Solvent Extracts and Major Bioactive Components from the Fruits of Crataegus pinnatifida

YT Lin, HR Lin, CS Yang, CC Liaw, PJ Sung, YH Kuo… - Antioxidants, 2022 - mdpi.com
Crataegus pinnatifida is used to treat various diseases, including indigestion, congestive
heart failure, hypertension, atherosclerosis, and myocardial dysfunction. We evaluated …

Synthesis of indole derivatives as diabetics II inhibitors and enzymatic kinetics study of α-glucosidase and α-amylase along with their in-silico study

M Taha, AS Alrashedy, NB Almandil, N Iqbal… - International journal of …, 2021 - Elsevier
In this study, we have investigated a series of indole-based compounds for their inhibitory
study against pancreatic α-amylase and intestinal α-glucosidase activity. Inhibitors of …

[HTML][HTML] Discovery of new α-glucosidase inhibitors: Structure-based virtual screening and biological evaluation

SK Liu, H Hao, Y Bian, YX Ge, S Lu, HX Xie… - Frontiers in …, 2021 - frontiersin.org
α-Glycosidase inhibitors could inhibit the digestion of carbohydrates into glucose and
promote glucose conversion, which have been used for the treatment of type 2 diabetes. In …

[HTML][HTML] Antidiabetic potential of novel 1, 3, 5-trisubstituted-2-thioxoimidazloidin-4-one analogues: Insights into α-glucosidase, α-amylase, and antioxidant activities

SM Khirallah, HMM Ramadan, HAA Aladl, NO Ayaz… - Pharmaceuticals, 2022 - mdpi.com
As the ninth leading cause of death globally, diabetes mellitus (DM) is considered to be the
worst chronic metabolic disease requiring an enormous need for healthcare with over 578 …

Combination of phenolic profiles, pharmacological properties and in silico studies to provide new insights on Silene salsuginea from Turkey

G Zengin, MJ Rodrigues, HH Abdallah… - … biology and chemistry, 2018 - Elsevier
The genus Silene is renowned in Turkey for its traditional use as food and medicine.
Currently, there are 138 species of Silene in Turkey, amongst which have been several …

Synthesis, α-glucosidase and α-amylase inhibitory activities, acute toxicity and molecular docking studies of thiazolidine-2, 4-diones derivatives

S Fettach, FZ Thari, Z Hafidi, H Tachallait… - Journal of …, 2022 - Taylor & Francis
In the present study, a series of thiazolidine-2, 4-diones derivatives (3a–3e) and (4a–4e)
were synthesized and characterized by 1H NMR, 13C NMR and ESI-MS spectrometry. All …