[HTML][HTML] Flavonoids as alpha-glucosidase inhibitors: Mechanistic approaches merged with enzyme kinetics and molecular modelling
D Şöhretoğlu, S Sari - Phytochemistry Reviews, 2020 - Springer
Diabetes mellitus is a major, global public health problem. α-Glucosidase inhibitors are one
of the most widely used classes of oral antidiabetics. In addition to other pharmaceutical …
of the most widely used classes of oral antidiabetics. In addition to other pharmaceutical …
Application of carbohydrates in approved small molecule drugs: A review
H Jiang, X Qin, Q Wang, Q Xu, J Wang, Y Wu… - European Journal of …, 2021 - Elsevier
Carbohydrates are an important energy source and play numerous key roles in all living
organisms. Carbohydrates chemistry involved in diagnosis and treatment of diseases has …
organisms. Carbohydrates chemistry involved in diagnosis and treatment of diseases has …
Synthesis, crystal structure, DFT, α-glucosidase and α-amylase inhibition and molecular docking studies of (E)-N'-(4-chlorobenzylidene)-5-phenyl-1H-pyrazole-3 …
In this work, a novel crystal ie (E)-N'-(4-chlorobenzylidene)-5-phenyl-1H-pyrazole-3-
carbohydrazide has been synthesized and characterized using various spectroscopic …
carbohydrazide has been synthesized and characterized using various spectroscopic …
[HTML][HTML] Comparison of Various Solvent Extracts and Major Bioactive Components from Portulaca oleracea for Antioxidant, Anti-Tyrosinase, and Anti-α-Glucosidase …
WC Chen, SW Wang, CW Li, HR Lin, CS Yang, YC Chu… - Antioxidants, 2022 - mdpi.com
Portulaca oleracea is a well-known species for traditional medicine and food homology in
Taiwan. In traditional medicine, P. oleracea is also used to treat gastrointestinal disorders …
Taiwan. In traditional medicine, P. oleracea is also used to treat gastrointestinal disorders …
[HTML][HTML] Antioxidant and Anti-α-Glucosidase Activities of Various Solvent Extracts and Major Bioactive Components from the Fruits of Crataegus pinnatifida
Crataegus pinnatifida is used to treat various diseases, including indigestion, congestive
heart failure, hypertension, atherosclerosis, and myocardial dysfunction. We evaluated …
heart failure, hypertension, atherosclerosis, and myocardial dysfunction. We evaluated …
Synthesis of indole derivatives as diabetics II inhibitors and enzymatic kinetics study of α-glucosidase and α-amylase along with their in-silico study
In this study, we have investigated a series of indole-based compounds for their inhibitory
study against pancreatic α-amylase and intestinal α-glucosidase activity. Inhibitors of …
study against pancreatic α-amylase and intestinal α-glucosidase activity. Inhibitors of …
[HTML][HTML] Discovery of new α-glucosidase inhibitors: Structure-based virtual screening and biological evaluation
SK Liu, H Hao, Y Bian, YX Ge, S Lu, HX Xie… - Frontiers in …, 2021 - frontiersin.org
α-Glycosidase inhibitors could inhibit the digestion of carbohydrates into glucose and
promote glucose conversion, which have been used for the treatment of type 2 diabetes. In …
promote glucose conversion, which have been used for the treatment of type 2 diabetes. In …
[HTML][HTML] Antidiabetic potential of novel 1, 3, 5-trisubstituted-2-thioxoimidazloidin-4-one analogues: Insights into α-glucosidase, α-amylase, and antioxidant activities
SM Khirallah, HMM Ramadan, HAA Aladl, NO Ayaz… - Pharmaceuticals, 2022 - mdpi.com
As the ninth leading cause of death globally, diabetes mellitus (DM) is considered to be the
worst chronic metabolic disease requiring an enormous need for healthcare with over 578 …
worst chronic metabolic disease requiring an enormous need for healthcare with over 578 …
Combination of phenolic profiles, pharmacological properties and in silico studies to provide new insights on Silene salsuginea from Turkey
G Zengin, MJ Rodrigues, HH Abdallah… - … biology and chemistry, 2018 - Elsevier
The genus Silene is renowned in Turkey for its traditional use as food and medicine.
Currently, there are 138 species of Silene in Turkey, amongst which have been several …
Currently, there are 138 species of Silene in Turkey, amongst which have been several …
Synthesis, α-glucosidase and α-amylase inhibitory activities, acute toxicity and molecular docking studies of thiazolidine-2, 4-diones derivatives
In the present study, a series of thiazolidine-2, 4-diones derivatives (3a–3e) and (4a–4e)
were synthesized and characterized by 1H NMR, 13C NMR and ESI-MS spectrometry. All …
were synthesized and characterized by 1H NMR, 13C NMR and ESI-MS spectrometry. All …