Autoantibody specificities in myasthenia gravis; implications for improved diagnostics and therapeutics

K Lazaridis, SJ Tzartos - Frontiers in immunology, 2020 - frontiersin.org
Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and
fatiguability of skeletal muscles. It is an antibody-mediated disease, caused by …

Seronegative autoimmune diseases: A challenging diagnosis

MV Lenti, CM Rossi, F Melazzini, M Gastaldi… - Autoimmunity …, 2022 - Elsevier
Autoimmune diseases (AID) are increasingly prevalent conditions which comprise more
than 100 distinct clinical entities that are responsible for a great disease burden worldwide …

Advances in the understanding of disease mechanisms of autoimmune neuromuscular junction disorders

MG Huijbers, A Marx, JJ Plomp, R Le Panse… - The Lancet …, 2022 - thelancet.com
Muscle weakness and fatigue are the hallmarks of autoimmune neuromuscular junction
disorders. Although a plethora of immunosuppressive treatments exist, no cure is available …

Myasthenia gravis: pathogenic effects of autoantibodies on neuromuscular architecture

I Koneczny, R Herbst - Cells, 2019 - mdpi.com
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ).
Autoantibodies target key molecules at the NMJ, such as the nicotinic acetylcholine receptor …

Role of complement, anti-complement therapeutics, and other targeted immunotherapies in myasthenia gravis

MC Dalakas - Expert Review of Clinical Immunology, 2022 - Taylor & Francis
Introduction Several patients with myasthenia gravis (MG) do not adequately respond to
available drugs or exhibit poor tolerance, necessitating the need for new therapies. Areas …

[HTML][HTML] Update on IgG4-mediated autoimmune diseases: new insights and new family members

I Koneczny - Autoimmunity Reviews, 2020 - Elsevier
Antibodies of IgG4 subclass are exceptional players of the immune system, as they are
considered to be immunologically inert and functionally monovalent, and as such may be …

Autoimmune pathology in myasthenia gravis disease subtypes is governed by divergent mechanisms of immunopathology

ML Fichtner, R Jiang, A Bourke, RJ Nowak… - Frontiers in …, 2020 - frontiersin.org
Myasthenia gravis (MG) is a prototypical autoantibody mediated disease. The
autoantibodies in MG target structures within the neuromuscular junction (NMJ), thus …

Myasthenia gravis with antibodies to MuSK: an update

A Evoli, PE Alboini, V Damato, R Iorio… - Annals of the New …, 2018 - Wiley Online Library
Myasthenia gravis with antibodies to the muscle‐specific tyrosine kinase (MuSK+ MG) is a
rare disease with distinctive pathogenic mechanisms and clinical features. An acute onset …

Myasthenia gravis: autoantibody specificities and their role in MG management

K Lazaridis, SJ Tzartos - Frontiers in neurology, 2020 - frontiersin.org
Myasthenia gravis (MG) is the most common autoimmune disorder affecting the
neuromuscular junction, characterized by skeletal muscle weakness and fatigability. It is …

A new classification system for IgG4 autoantibodies

I Koneczny - Frontiers in immunology, 2018 - frontiersin.org
IgG4 autoimmune diseases are characterized by the presence of antigen-specific
autoantibodies of the IgG4 subclass and contain well-characterized diseases such as …