Microglia are so versatile that they not only provide immune surveillance for central nervous
system, but participate in neural circuitry development, brain blood vessels formation, blood …

Major depressive disorder (MDD) is a debilitating neuropsychological disorder, which has
caused serious health and socio-economic burdens worldwide. A growing body of evidence …

Cancer immunotherapies have yielded promising outcomes in various malignant tumors by
blocking specific immune checkpoint molecules, such as programmed cell death 1 and …

Background Bipolar disorder (BD) is associated with marked functional impairments along
with increased rate of suicide. Although there is ample evidence for the involvement of …

Background Microglia have been implicated in the pathophysiology of major depressive
disorder (MDD), but information on biological mechanisms is limited. Therefore, we …

Social behavior is essential for the well-being and survival of individuals. However, social
isolation is a serious public health issue, especially during the COVID-19 pandemic …

Bipolar disorder (BD) is a severe and multifactorial disease, with onset usually in young
adulthood, which follows a progressive course throughout life. Replicated epidemiological …

Depression stands as a prominent contributor to global disability, entailing an elevated risk
of suicide. Substantial evidence supports the notion that immune dysregulation may play a …

Chronic stress significantly elevates the expression levels of various neurotransmitters in the
tumour microenvironment, thereby promoting the cell growth and metastasis of lung …

We and others have reported that systematic stimulation of the central innate immune
system by a low dose of lipopolysaccharide (LPS) can improve depression-like behavior in …