Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor
B Jena, G Dotti, LJN Cooper - Blood, The Journal of the …, 2010 - ashpublications.org
Infusions of antigen-specific T cells have yielded therapeutic responses in patients with
pathogens and tumors. To broaden the clinical application of adoptive immunotherapy …
pathogens and tumors. To broaden the clinical application of adoptive immunotherapy …
Gene therapy for cancer treatment: past, present and future
D Cross, JK Burmester - Clinical medicine & research, 2006 - Marshfield Clinic
The broad field of gene therapy promises a number of innovative treatments that are likely to
become important in preventing deaths from cancer. In this review, we discuss the history …
become important in preventing deaths from cancer. In this review, we discuss the history …
CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma
S Prommersberger, M Reiser, J Beckmann, S Danhof… - Gene therapy, 2021 - nature.com
Clinical development of chimeric antigen receptor (CAR)-T-cell therapy has been enabled
by advances in synthetic biology, genetic engineering, clinical-grade manufacturing, and …
by advances in synthetic biology, genetic engineering, clinical-grade manufacturing, and …
Efficient TALEN-mediated gene knockout in livestock
DF Carlson, W Tan, SG Lillico… - Proceedings of the …, 2012 - National Acad Sciences
Transcription activator-like effector nucleases (TALENs) are programmable nucleases that
join FokI endonuclease with the modular DNA-binding domain of TALEs. Although zinc …
join FokI endonuclease with the modular DNA-binding domain of TALEs. Although zinc …
Polymers for gene delivery across length scales
D Putnam - Nature materials, 2006 - nature.com
A number of human diseases stem from defective genes. One approach to treating such
diseases is to replace, or override, the defective genes with normal genes, an approach …
diseases is to replace, or override, the defective genes with normal genes, an approach …
SPION decorated exosome delivery of TNF-α to cancer cell membranes through magnetism
M Zhuang, X Chen, D Du, J Shi, M Deng, Q Long, X Yin… - Nanoscale, 2020 - pubs.rsc.org
Tumor necrosis factor (TNF-α) is capable of inducing apoptosis and is a promising candidate
for genetic engineering drugs in cancer therapy; however, the serious side-effects of TNF-α …
for genetic engineering drugs in cancer therapy; however, the serious side-effects of TNF-α …
Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors
C Baum, O Kustikova, U Modlich, Z Li… - Human gene therapy, 2006 - liebertpub.com
Increasing evidence reveals that random insertion of gene transfer vectors into the genome
of repopulating hematopoietic cells may alter their fate in vivo. Although most insertional …
of repopulating hematopoietic cells may alter their fate in vivo. Although most insertional …
Gene therapy with the sleeping beauty transposon system
The widespread clinical implementation of gene therapy requires the ability to stably
integrate genetic information through gene transfer vectors in a safe, effective, and …
integrate genetic information through gene transfer vectors in a safe, effective, and …
A transposon and transposase system for human application
PB Hackett, DA Largaespada, LJN Cooper - Molecular therapy, 2010 - cell.com
The stable introduction of therapeutic transgenes into human cells can be accomplished
using viral and nonviral approaches. Transduction with clinical-grade recombinant viruses …
using viral and nonviral approaches. Transduction with clinical-grade recombinant viruses …
Gene therapy progress and prospects: hydrodynamic gene delivery
H Herweijer, JA Wolff - Gene therapy, 2007 - nature.com
Over the last few years, hydrodynamic tail vein delivery has established itself as a simple,
yet very effective method for gene transfer into small rodents. Hydrodynamic delivery of …
yet very effective method for gene transfer into small rodents. Hydrodynamic delivery of …