Nucleoid‐associated proteins of mycobacteria come with a distinctive flavor

M Santoshi, P Tare, V Nagaraja - Molecular Microbiology, 2024 - Wiley Online Library
In every bacterium, nucleoid‐associated proteins (NAPs) play crucial roles in chromosome
organization, replication, repair, gene expression, and other DNA transactions. Their central …

Population heterogeneity in Mycobacterium smegmatis and Mycobacterium abscessus

SEM Born, MJ Reichlen, IL Bartek, JB Benoit… - …, 2023 - microbiologyresearch.org
Bacteria use population heterogeneity, the presence of more than one phenotypic variant in
a clonal population, to endure diverse environmental challenges–a 'bet-hedging'strategy …

A nucleoid-associated protein is involved in the emergence of antibiotic resistance by promoting the frequent exchange of the replicative DNA polymerase in …

WL Ng, EH Rego - Msphere, 2024 - Am Soc Microbiol
Antibiotic resistance in Mycobacterium tuberculosis exclusively originates from
chromosomal mutations, either during normal DNA replication or under stress, when the …

Lsr2, a pleiotropic regulator at the core of the infectious strategy of Mycobacterium abscessus

E Gerges, MP Rodriguez-Ordonez… - Microbiology …, 2024 - Am Soc Microbiol
Mycobacterium abscessus is a non-tuberculous mycobacterium, causing lung infections in
cystic fibrosis patients. During pulmonary infection, M. abscessus switches from smooth …

Zafirlukast induces DNA condensation and has bactericidal effect on replicating Mycobacterium abscessus

S Niet, KD Green, IM Schimmel, J Bakker… - Antimicrobial Agents …, 2024 - journals.asm.org
Mycobacterium abscessus infections are emerging in cystic fibrosis patients, and treatment
success rate in these patients is only 33% due to extreme antibiotic resistance. Thus, new …

[HTML][HTML] Dissecting the metal resistance genes contributed by virome from mining-affected metal contaminated soils

H Zhang, J Huang, W Zeng, Q Xiao, Y Zhu… - Frontiers in …, 2023 - frontiersin.org
Virus-borne auxiliary genes have been demonstrated to influence their hosts' characteristics
and flexibility, resulting in an elevated ability to withstand diverse conditions and …

[HTML][HTML] Gene expression during the development of Mycobacterium smegmatis biofilms on hydroxyapatite surfaces

J Juárez-Cepeda, O Valenzuela… - International …, 2024 - Springer
Bacterial biofilms are a consortium of bacteria that are strongly bound to each other and the
surface on which they developed irreversibly. Bacteria can survive adverse environmental …

[HTML][HTML] Dynamic Transcriptional Landscape of Mycobacterium smegmatis under Cold Stress

AS Grigorov, YV Skvortsova, OS Bychenko… - International Journal of …, 2023 - mdpi.com
Bacterial adaptation to cold stress requires wide transcriptional reprogramming. However,
the knowledge of molecular mechanisms underlying the cold stress response of …

Insertion sequence transposition activates antimycobacteriophage immunity through an lsr2‐silenced lipid metabolism gene island

Y Li, Y Wei, X Guo, X Li, L Lu, L Hu, ZG He - Mlife, 2024 - Wiley Online Library
Insertion sequences (ISs) exist widely in bacterial genomes, but their roles in the evolution of
bacterial antiphage defense remain to be clarified. Here, we report that, under the pressure …

[HTML][HTML] Mycobacterial IHF is a highly dynamic nucleoid-associated protein that assists HupB in organizing chromatin

J Hołówka, T Łebkowski, H Feddersen… - Frontiers in …, 2023 - frontiersin.org
Nucleoid-associated proteins (NAPs) crucially contribute to organizing bacterial chromatin
and regulating gene expression. Among the most highly expressed NAPs are the HU and …