The protein kinase family: conserved features and deduced phylogeny of the catalytic domains
In recent years, members of the protein kinase family have been discovered at an
accelerated pace. Most were first described, not through the traditional biochemical …
accelerated pace. Most were first described, not through the traditional biochemical …
An analysis of vertebrate mRNA sequences: intimations of translational control.
M Kozak - The Journal of cell biology, 1991 - rupress.org
Five structural features in mRNAs have been found to contribute to the fidelity and efficiency
of initiation by eukaryotic ribosomes. Scrutiny of vertebrate cDNA sequences in light of these …
of initiation by eukaryotic ribosomes. Scrutiny of vertebrate cDNA sequences in light of these …
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins
CA Koch, D Anderson, MF Moran, C Ellis, T Pawson - Science, 1991 - science.org
Src homology (SH) regions 2 and 3 are noncatalytic domains that are conserved among a
series of cytoplasmic signaling proteins regulated by receptor protein-tyrosine kinases …
series of cytoplasmic signaling proteins regulated by receptor protein-tyrosine kinases …
A thousand and one protein kinases
T Hunter - Cell, 1987 - Elsevier
Ten years ago there were less than a dozen well-characterized protein kinases. With the
advent of molecular cloning and the discovery that many oncogenes encode protein …
advent of molecular cloning and the discovery that many oncogenes encode protein …
Myristoylation
JA Boutin - Cellular signalling, 1997 - Elsevier
N-myristoylation is an acylation process absolutely specific to the N-terminal amino acid
glycine in proteins. This maturation process concerns about a hundred proteins in lower and …
glycine in proteins. This maturation process concerns about a hundred proteins in lower and …
[HTML][HTML] CSK: a protein-tyrosine kinase involved in regulation of src family kinases.
M Okada, S Nada, Y Yamanashi, T Yamamoto… - Journal of Biological …, 1991 - Elsevier
The functions of src family protein-tyrosine kinases are thought to be regulated negatively by
the phosphorylation of highly conserved tyrosine residues close to their carboxyl termini …
the phosphorylation of highly conserved tyrosine residues close to their carboxyl termini …
Lyn tyrosine kinase: accentuating the positive and the negative
Y Xu, KW Harder, ND Huntington, ML Hibbs… - Immunity, 2005 - cell.com
Lyn, one of several Src-family tyrosine kinases in immune cells, is noted for its ability to
negatively regulate signaling pathways through phosphorylation of inhibitory receptors …
negatively regulate signaling pathways through phosphorylation of inhibitory receptors …
Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas
Gene expression profiling has proven useful in subclassification and outcome
prognostication for human glial brain tumors. The analysis of biological significance of the …
prognostication for human glial brain tumors. The analysis of biological significance of the …
Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation
TE Kmiecik, D Shalloway - Cell, 1987 - cell.com
Summary pp6OC-S'C is phosphorylated in vivo at tyrosine 527, a residue not present in
pp60v-Jrc (its transforming homolog), and not at tyrosine 416, its site of in vitro …
pp60v-Jrc (its transforming homolog), and not at tyrosine 416, its site of in vitro …
Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: rationale for patient selection
F Huang, K Reeves, X Han, C Fairchild, S Platero… - Cancer research, 2007 - AACR
Dasatinib is a multitargeted kinase inhibitor that was recently approved for the treatment of
chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphoblastic …
chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphoblastic …