Human metabolites of cannabidiol: a review on their formation, biological activity, and relevance in therapy
I Ujváry, L Hanuš - Cannabis and cannabinoid research, 2016 - liebertpub.com
Cannabidiol (CBD), the main nonpsychoactive constituent of Cannabis sativa, has shown a
wide range of therapeutically promising pharmacological effects either as a sole drug or in …
wide range of therapeutically promising pharmacological effects either as a sole drug or in …
[HTML][HTML] An overview on medicinal chemistry of synthetic and natural derivatives of cannabidiol
P Morales, PH Reggio, N Jagerovic - Frontiers in pharmacology, 2017 - frontiersin.org
Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however
historically, it has received far less interest as a single drug than the other components of …
historically, it has received far less interest as a single drug than the other components of …
Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation
INTRODUCTION Infection causes inflammation, which contributes to pathogen clearance
and organismal survival. The balance between the intensity and resolution of an …
and organismal survival. The balance between the intensity and resolution of an …
An overview on synthetic and biological activities of cannabidiol (CBD) and its derivatives
X Wang, H Zhang, Y Liu, Y Xu, B Yang, H Li… - Bioorganic Chemistry, 2023 - Elsevier
Cannabidiol is a class of non-psychoactive plant cannabinoids derived from cannabis
plants. Currently, Epidiolex (Cannabidiol) has been approved by the FDA for the treatment of …
plants. Currently, Epidiolex (Cannabidiol) has been approved by the FDA for the treatment of …
The oxidation of phytocannabinoids to cannabinoquinoids
D Caprioglio, D Mattoteia, F Pollastro… - Journal of Natural …, 2020 - ACS Publications
Spurred by a growing interest in cannabidiolquinone (CBDQ, HU-313, 2) as a degradation
marker and alledged hepatotoxic metabolite of cannabidiol (CBD, 1), we performed a …
marker and alledged hepatotoxic metabolite of cannabidiol (CBD, 1), we performed a …
Towards anticancer fluoroquinolones: A review article
MAA Abdel‐Aal, SA Abdel‐Aziz… - Archiv der …, 2019 - Wiley Online Library
Different studies about the anticancer potential of several medically used antibacterial
fluoroquinolones have been established. Fluoroquinolone derivatives, like some anti …
fluoroquinolones have been established. Fluoroquinolone derivatives, like some anti …
Examining the impact of antimicrobial fluoroquinolones on human DNA topoisomerase IIα and IIβ
CA Fief, KG Hoang, SD Phipps, JL Wallace… - ACS …, 2019 - ACS Publications
Fluoroquinolones are a class of widely prescribed antibiotics with a broad range of activity
against Gram-positive, Gram-negative, and some atypical microbes. Unfortunately, these …
against Gram-positive, Gram-negative, and some atypical microbes. Unfortunately, these …
[HTML][HTML] Cannabinoid quinones—A review and novel observations
NM Kogan, M Peters, R Mechoulam - Molecules, 2021 - mdpi.com
A cannabinoid anticancer para-quinone, HU-331, which was synthesized by our group five
decades ago, was shown to have very high efficacy against human cancer cell lines in-vitro …
decades ago, was shown to have very high efficacy against human cancer cell lines in-vitro …
A “Double-Edged” scaffold: antitumor power within the antibacterial quinolone
GS Bisacchi, MR Hale - Current Medicinal Chemistry, 2016 - ingentaconnect.com
In the late 1980s, reports emerged describing experimental antibacterial quinolones having
significant potency against eukaryotic Type II topoisomerases (topo II) and showing cytotoxic …
significant potency against eukaryotic Type II topoisomerases (topo II) and showing cytotoxic …
Examination of the Impact of Copper(II) α-(N)-Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIα
JT Wilson, X Jiang, BC McGill, EC Lisic… - Chemical research in …, 2016 - ACS Publications
Type II DNA topoisomerases resolve topological knots and tangles in DNA that result from
routine cellular processes and are effective targets for anticancer therapeutics. To this end …
routine cellular processes and are effective targets for anticancer therapeutics. To this end …