Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Glycosylation, the addition of glycans or carbohydrates to proteins, lipids, or other glycans, is
a complex post-translational modification that plays a crucial role in cellular function. It is …

Alzheimer's disease (AD) is the most common cause of dementia, affecting millions of
people worldwide, and no cure is currently available. The major pathological hallmarks of …

Glycosylation defects are a hallmark of many nervous system diseases. However, the
molecular and metabolic basis for this pathology is not fully understood. In this study, we …

Capillary electrophoresis has emerged as a powerful approach for carbohydrate analyses
since 2014. The method provides high resolution capable of separating carbohydrates by …

Protein N-glycosylation plays critical roles in controlling brain function, but little is known
about human brain N-glycoproteome and its alterations in Alzheimer's disease (AD). Here …

Alzheimer's disease (AD) is the most common cause of dementia, with no current cure.
Consequently, alternative approaches focusing on early pathological events in specific …

Highlights•Recent advancements in glycoinformatics tools to support analysis of glycan and
glycopeptide data sets are summarised.•Review summarises the growth of machine …

Abstract Changes in the glycome of human proteins and cells are associated with the
progression of multiple diseases such as Alzheimer's, diabetes mellitus, many types of …