Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents
C Lugnier - Pharmacology & therapeutics, 2006 - Elsevier
Cyclic nucleotide phosphodiesterases (PDEs), which are ubiquitously distributed in
mammalian tissues, play a major role in cell signaling by hydrolyzing cAMP and cGMP. Due …
mammalian tissues, play a major role in cell signaling by hydrolyzing cAMP and cGMP. Due …
Cyclic nucleotide phosphodiesterases
DM Essayan - Journal of Allergy and Clinical Immunology, 2001 - Elsevier
Cyclic nucleotide second messengers (cAMP and cGMP) play a central role in signal
transduction and regulation of physiologic responses. Their intracellular levels are …
transduction and regulation of physiologic responses. Their intracellular levels are …
The molecular biology of phosphodiesterase 4 enzymes as pharmacological targets: an interplay of isoforms, conformational states, and inhibitors
Abstract The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating
levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been …
levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been …
Blueberry-derived exosome-like nanoparticles counter the response to TNF-α-induced change on gene expression in EA. hy926 cells
Exosome-like nanoparticles (ELNs) are attracting interest as important vehicles of
intercellular communication, both in prokaryotes and eukaryotes. Recently, dietary …
intercellular communication, both in prokaryotes and eukaryotes. Recently, dietary …
[HTML][HTML] Phosphodiesterases as therapeutic targets for respiratory diseases
H Zuo, I Cattani-Cavalieri, N Musheshe… - Pharmacology & …, 2019 - Elsevier
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and
asthma, affect millions of people all over the world. Cyclic adenosine monophosphate …
asthma, affect millions of people all over the world. Cyclic adenosine monophosphate …
Phosphodiesterases in heart and vessels-From Physiology to Diseases
Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides,
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …
Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization
S Pérez-Torres, R Cortés, M Tolnay, A Probst… - Experimental …, 2003 - Elsevier
Phosphodiesterases (PDEs) play a central role in signal transduction by regulating
intracellular levels of cyclic AMP (cAMP) and cGMP. It has been suggested that cAMP …
intracellular levels of cyclic AMP (cAMP) and cGMP. It has been suggested that cAMP …
[图书][B] Cyclic nucleotide phosphodiesterases in health and disease
J Beavo, SH Francis, MD Houslay - 2007 - api.taylorfrancis.com
The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …
Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells
SJ Smith, S Brookes-Fazakerley… - … of Physiology-Lung …, 2003 - journals.physiology.org
We have determined the expression of phosphodiesterase (PDE) 7A1 and PDE7A2 in
human cells that have been implicated in the pathogenesis of chronic obstructive pulmonary …
human cells that have been implicated in the pathogenesis of chronic obstructive pulmonary …
VEGF-induced HUVEC migration and proliferation are decreased by PDE2 and PDE4 inhibitors
L Favot, T Keravis, V Holl, A Le Bec… - Thrombosis and …, 2003 - thieme-connect.com
Migration and proliferation of endothelial cells in response to VEGF play an important role in
angiogenesis associated to pathologies such as atherosclerosis, diabetes and tumor …
angiogenesis associated to pathologies such as atherosclerosis, diabetes and tumor …