Repurposing sigma-1 receptor ligands for COVID-19 therapy?
JM Vela - Frontiers in Pharmacology, 2020 - frontiersin.org
Outbreaks of emerging infections, such as COVID-19 pandemic especially, confront health
professionals with the unique challenge of treating patients. With no time to discover new …
professionals with the unique challenge of treating patients. With no time to discover new …
The molecular function of σ receptors: past, present, and future
HR Schmidt, AC Kruse - Trends in pharmacological sciences, 2019 - cell.com
The σ 1 and σ 2 receptors are enigmatic proteins that have attracted attention for decades
due to the chemical diversity and therapeutic potential of their ligands. However, despite …
due to the chemical diversity and therapeutic potential of their ligands. However, despite …
Sigmar1's molecular, cellular, and biological functions in regulating cellular pathophysiology
The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers
Macroautophagy/autophagy plays a critical role in the pathogenesis of various human
diseases including neurodegenerative disorders such as Parkinson disease (PD) and …
diseases including neurodegenerative disorders such as Parkinson disease (PD) and …
Antipsychotics function as epigenetic age regulators in human neuroblastoma cells
Recent epigenetic age studies suggested accelerated aging in schizophrenia. Although
antipsychotics may modulate epigenetic age, direct estimation of their roles was impeded …
antipsychotics may modulate epigenetic age, direct estimation of their roles was impeded …
[HTML][HTML] Ligand docking in the sigma-1 receptor compared to the sigma-1 receptor-BiP complex and the effects of agonists and antagonists on C. elegans lifespans
Abstract Model organisms are commonly used to study human diseases; we set out to
understand the relevance of several model organisms with relation to the σ1R protein. The …
understand the relevance of several model organisms with relation to the σ1R protein. The …
The efficacy and safety of haloperidol for the treatment of delirium in critically ill patients: a systematic review and meta-analysis of randomized controlled trials
J Huang, H Zheng, X Zhu, K Zhang, X Ping - Frontiers in Medicine, 2023 - frontiersin.org
Purpose Delirium is common during critical illness and is associated with poor outcomes.
Therefore, we conducted this meta-analysis to investigate the efficacy and safety of …
Therefore, we conducted this meta-analysis to investigate the efficacy and safety of …
[HTML][HTML] High-throughput screening discovers antifibrotic properties of haloperidol by hindering myofibroblast activation
Fibrosis is a hallmark in the pathogenesis of various diseases, with very limited therapeutic
solutions. A key event in the fibrotic process is the expression of contractile proteins …
solutions. A key event in the fibrotic process is the expression of contractile proteins …
[PDF][PDF] Cardiac sigma receptors-an update.
T Stracina, M Nováková - Physiological Research, 2018 - biomed.cas.cz
More than four decades passed since sigma receptors were first mentioned. Since then,
existence of at least two receptor subtypes and their tissue distributions have been …
existence of at least two receptor subtypes and their tissue distributions have been …
The unfolded protein response and autophagy as drug targets in neuropsychiatric disorders
V Srinivasan, L Korhonen, D Lindholm - Frontiers in Cellular …, 2020 - frontiersin.org
Neurons are polarized in structure with a cytoplasmic compartment extending into dendrites
and a long axon that terminates at the synapse. The high level of compartmentalization …
and a long axon that terminates at the synapse. The high level of compartmentalization …