TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …

Abstract TAR DNA-binding protein 43 (TDP-43) is a highly conserved nuclear RNA/DNA-
binding protein involved in the regulation of RNA processing. The accumulation of TDP-43 …

Over a century ago, colloidal phase separation of matter into non-membranous bodies was
recognized as a fundamental organizing principal of cell" protoplasm." Recent insights into …

Prions are self-templating protein conformers that are naturally transmitted between
individuals and promote phenotypic change. In yeast, prion-encoded phenotypes can be …

The concept of a prion as an infectious self-propagating protein isoform was initially
proposed to explain certain mammalian diseases. It is now clear that yeast also has …

Background The folding of proteins is challenging in the highly crowded and sticky
environment of a cell. Regulation of translation elongation may play a crucial role in …

Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. This
phenomenon has largely been studied in the context of chromatin modification. Yet many …

Prions are proteins that access self-templating amyloid forms, which confer phenotypic
changes that can spread from individual to individual within or between species. These …

Prion conversion from a soluble protein to an aggregated state may be involved in the
cellular adaptation of yeast to the environment. However, it remains unclear whether and …

The functional switch of glutamine/asparagine (Q/N)-rich prions and the neurotoxicity of
polyQ-expanded proteins involve complex aggregation-prone structural transitions …