Explaining dopamine through prediction errors and beyond
The most influential account of phasic dopamine holds that it reports reward prediction
errors (RPEs). The RPE-based interpretation of dopamine signaling is, in its original form …
errors (RPEs). The RPE-based interpretation of dopamine signaling is, in its original form …
Midbrain KCC2 downregulation: Implications for stress-related and substance use behaviors
AC Pearson, A Ostroumov - Current Opinion in Neurobiology, 2024 - Elsevier
Highlights•In VTA GABA neurons, KCC2 is downregulated by stress and drug
use.•Downregulation of KCC2 is associated with a variety of behavioral changes.•KCC2 …
use.•Downregulation of KCC2 is associated with a variety of behavioral changes.•KCC2 …
Different learning aberrations relate to delusion-like beliefs with different contents
R Rossi-Goldthorpe, SM Silverstein, JM Gold… - Brain, 2024 - academic.oup.com
The prediction error account of delusions has had success. However, its explanation of
delusions with different contents has been lacking. Persecutory delusions and paranoia are …
delusions with different contents has been lacking. Persecutory delusions and paranoia are …
Mesostriatal dopamine is sensitive to changes in specific cue-reward contingencies
Learning causal relationships relies on understanding how often one event precedes
another. To investigate how dopamine neuron activity and neurotransmitter release change …
another. To investigate how dopamine neuron activity and neurotransmitter release change …
Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation
Ventral tegmental area (VTA) dopamine neurons regulate reward-related associative
learning and reward-driven motivated behaviors, but how these processes are coordinated …
learning and reward-driven motivated behaviors, but how these processes are coordinated …
Unraveling the Pathogenesis of Post‐Stroke Depression in a Hemorrhagic Mouse Model through Frontal Lobe Circuitry and JAK‐STAT Signaling
Y Wu, J Deng, J Ma, Y Chen, N Hu, S Hao… - Advanced …, 2024 - Wiley Online Library
Post‐stroke depression is a common complication that imposes significant burdens and
challenges on patients. The occurrence of depression is often associated with frontal lobe …
challenges on patients. The occurrence of depression is often associated with frontal lobe …
Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning
Environmental cues, through Pavlovian learning, become conditioned stimuli that invigorate
and guide animals toward rewards. Dopamine (DA) neurons in the ventral tegmental area …
and guide animals toward rewards. Dopamine (DA) neurons in the ventral tegmental area …
Mating proximity blinds threat perception.
L Cazale Debat, L Scheunemann, M Day… - bioRxiv, 2024 - biorxiv.org
Romantic engagement can bias sensory perception. This' love blindness' reflects a common
behavioral principle across organisms: favoring pursuit of a coveted reward over potential …
behavioral principle across organisms: favoring pursuit of a coveted reward over potential …
Depression in Parkinson's disease is associated with dopamine unresponsive reduced reward sensitivity during effort-based decision making
H Costello, Y Yamamori, K Kieslich, M Murphy… - bioRxiv, 2024 - biorxiv.org
Willingness to exert effort for a given goal is dependent on the magnitude of the potential
rewards and effort costs of an action. Such effort-based decision making is an essential …
rewards and effort costs of an action. Such effort-based decision making is an essential …
Dopamine reveals adaptive learning of actions representation
M Come, A Gulmez, L Keshishian, J Jehl, E Bousseyrol… - bioRxiv, 2024 - biorxiv.org
Efficient decision-making requires two key processes: learning values from actions and
identifying a set of relevant actions to learn from in a given context. While dopamine (DA) is …
identifying a set of relevant actions to learn from in a given context. While dopamine (DA) is …