Using PyMOL as a platform for computational drug design
PyMOL, a cross‐platform molecular graphics tool, has been widely used for three‐
dimensional (3D) visualization of proteins, nucleic acids, small molecules, electron …
dimensional (3D) visualization of proteins, nucleic acids, small molecules, electron …
[HTML][HTML] Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
The emergence and global spread of SARS-CoV-2 has resulted in the urgent need for an in-
depth understanding of molecular functions of viral proteins and their interactions with the …
depth understanding of molecular functions of viral proteins and their interactions with the …
[PDF][PDF] Posttranslational modifications mediate the structural diversity of tauopathy strains
Tau aggregation into insoluble filaments is the defining pathological hallmark of tauopathies.
However, it is not known what controls the formation and templated seeding of strain-specific …
However, it is not known what controls the formation and templated seeding of strain-specific …
[HTML][HTML] Using phosphoproteomics data to understand cellular signaling: a comprehensive guide to bioinformatics resources
Mass spectrometry-based phosphoproteomics is becoming an essential methodology for the
study of global cellular signaling. Numerous bioinformatics resources are available to …
study of global cellular signaling. Numerous bioinformatics resources are available to …
[HTML][HTML] EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation
L Zhang, J Qu, Y Qi, Y Duan, YW Huang, Z Zhou… - Nature …, 2022 - nature.com
Abstract Bone metastases occur in 50–70% of patients with late-stage breast cancers and
effective therapies are needed. The expression of enhancer of zeste homolog 2 (EZH2) is …
effective therapies are needed. The expression of enhancer of zeste homolog 2 (EZH2) is …
[HTML][HTML] Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
Phosphorylation of the MLKL pseudokinase by the RIPK3 kinase leads to MLKL
oligomerization, translocation to, and permeabilization of, the plasma membrane to induce …
oligomerization, translocation to, and permeabilization of, the plasma membrane to induce …
Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy
Mitophagy is an essential intracellular process that eliminates dysfunctional mitochondria
and maintains cellular homeostasis. Mitophagy is regulated by the post-translational …
and maintains cellular homeostasis. Mitophagy is regulated by the post-translational …
[HTML][HTML] Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
KA Davies, C Fitzgibbon, SN Young… - Nature …, 2020 - nature.com
The MLKL pseudokinase is the terminal effector in the necroptosis cell death pathway.
Phosphorylation by its upstream regulator, RIPK3, triggers MLKL's conversion from a …
Phosphorylation by its upstream regulator, RIPK3, triggers MLKL's conversion from a …
Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α
Cellular adaptation to low-oxygen environments is mediated in part by the hypoxia-inducible
factors (HIFs). Like other transcription factors, the stability and transcriptional activity of HIFs …
factors (HIFs). Like other transcription factors, the stability and transcriptional activity of HIFs …
[HTML][HTML] How multisite phosphorylation impacts the conformations of intrinsically disordered proteins
Phosphorylation of intrinsically disordered proteins (IDPs) can produce changes in structural
and dynamical properties and thereby mediate critical biological functions. How …
and dynamical properties and thereby mediate critical biological functions. How …