A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

Since the emergence of HIV and AIDS in the early 1980s, the development of safe and
effective therapies has accompanied a massive increase in our understanding of the …

The internal N 6-methyladenosine (m 6 A) modification of cellular mRNA regulates post-
transcriptional gene expression. The YTH domain family proteins (YTHDF1–3 or Y1–3) bind …

During retrovirus maturation, cleavage of the precursor structural Gag polyprotein by the
viral protease induces architectural rearrangement of the virus particle from an immature into …

Integration is central to HIV-1 replication and helps mold the reservoir of cells that persists in
AIDS patients. HIV-1 interacts with specific cellular factors to target integration to interior …

Systematic Evolution of Ligands by Exponential Enrichment (SELEX) is the iterative process
by which nucleic acids that can bind with high affinity and specificity (termed aptamers) to …

Members of the family Retroviridae are important animal and human pathogens. Being
obligate parasites, their replication involves a series of steps during which the virus hijacks …

Antiretroviral inhibitors that are used to manage HIV infection/AIDS predominantly target
three enzymes required for virus replication: reverse transcriptase, protease, and integrase …

Human immunodeficiency virus type 1 (HIV-1) particle assembly requires several protein:
RNA interactions that vary widely in their character, from specific recognition of highly …

Integrase is the retroviral protein responsible for integrating reverse transcripts into cellular
genomes. Co-packaged with viral RNA and reverse transcriptase into capsid-encased viral …