Across complex, multi-time and-length scale biological systems, redundancy confers
robustness and resilience, enabling adaptation and increasing survival under dynamic …

Over the past decade, researchers have highlighted the importance of mechanical cues of
the metastatic niche such as matrix stiffness, topography, mechanical stresses, and …

Single cardiomyocytes contain myofibrils that harbor the sarcomere-based contractile
machinery of the myocardium. Cardiomyocytes differentiated from human pluripotent stem …

Forces generated by the cytoskeleton can be transmitted to the nucleus and chromatin via
physical links on the nuclear envelope and the lamin meshwork. Although the role of these …

Bioprinting could spatially align various cells in high accuracy to simulate complex and
highly organized native tissues. However, the uniform suspension and low concentration of …

In this study, we designed a cell-adhesive poly (ethylene glycol)(PEG)-based hydrogel that
simultaneously provides topographical and electrical stimuli to C2C12 myoblasts …

Clinically relevant in vitro models of human tissue's health and disease are urgently needed
for a better understanding of biological mechanisms essential for the development of novel …

Cell mechanics is crucial for a wide range of cell functions, including proliferation, polarity,
migration and differentiation. Cells sense external physical cues and translate them into a …

Human cells are both advanced pharmaceutical drugs and 'drug deliverers'. However,
functional control prior to or after cell implantation remains challenging. Micro-patterning …

Patterned structured surfaces are very useful to control a cell's microenvironment and to
modulate certain cellular responses, such as cell adhesion, migration, proliferation, and …