Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

Zinc is essential to all forms of life, 1-4 with an average adult human containing ca. 3 g of
zinc. 5 For example, zinc is indispensable for effective growth and development, has …

DNA hydrolysis mediated by di-and multi-nuclear metal complexes is of increasing
importance in biotechnology and medicine. Many systems for enzyme-mediated nucleic acid …

Cyclams are 14-membered tetraamine macrocycles which bind strongly to a wide range of
metal ions. Medical interest has centred on clinical trials of a bicyclam for the treatment of …

Substantial progress is being made in the synthesis of functional mimics of metallonuclease
enzymes, although a comparison with enzyme-promoted rates of reaction shows …

The manipulation of phosphate ester linkages is very important in the chemistry of life. Cells
possess highly evolved enzymatic machinery to make and break these linkages, which are …

In living organisms it is necessary to be able to perform countless hydrolysis reactions
efficiently and, above all, selectively to sustain thousands, maybe even millions, of critical …

Micelles are prevalent in naturally occurring and biological catalytic reactions. However, it is
only in recent decades that scientists have developed kinetic models clarifying how micelle …

The development of synthetic agents able to hydrolytically cleave DNA with high efficiency
and selectivity is a fascinating challenge that will show the way to obtaining artificial …

'Acridine'along with its functional analogue 'Acridone'is the most privileged pharmacophore
in medicinal chemistry with diverse applications ranging from DNA intercalators …