A major development of carcinogenesis research in the past 20 years has been the
discovery of significant levels of DNA damage arising from endogenous cellular sources …

DNA damage plays a major role in mutagenesis, carcinogenesis and ageing. The vast
majority of mutations in human tissues are certainly of endogenous origin. A thorough …

Glucose dependency of cancer cells can be targeted with a high-fat, low-carbohydrate
ketogenic diet (KD). However, in IL-6-producing cancers, suppression of the hepatic …

Oxidative stress and resulting lipid peroxidation is involved in various and numerous
pathological states including inflammation, atherosclerosis, neurodegenerative diseases …

Increasing evidence from animal and in vitro studies indicates that n− 3 fatty acids,
especially the long-chain polyunsaturated fatty acids eicosapentaenoic acid and …

Canola oil-based diets have been shown to reduce plasma cholesterol levels in comparison
with diets containing higher levels of saturated fatty acids. Consumption of canola oil also …

The hypothesis that a high-fat diet promotes the development of postmenopausal breast
cancer is supported by international data showing a strong correlation between fat intake …

Persistent oxidative stress and excess lipid peroxidation (LPO), induced by inflammatory
processes, impaired metal storage, and/or dietary imbalance, cause accumulations and …

Modification of cellular DNA upon exposure to reactive oxygen and nitrogen species is the
likely initial event involved in the induction of the mutagenic and lethal effects of various …

In humans, approximately 10 7 cells divide per second. Estimates suggest that spontaneous
mutations arise in about a third of those cells. These mutations arise as mistakes in DNA …