Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …

In the last decade, we witnessed discoveries that established Zn2+ as a second major
signalling metal ion in the transmission of information within cells and in communication …

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of secreted
proteins. Signaling cascades induced by BDNF and its receptor, the receptor tyrosine kinase …

Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …

Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are crucial for many forms of
neuronal plasticity,,,,,, including structural long-term potentiation (sLTP),, which is a correlate …

Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …

Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

Copper-containing enzymes perform fundamental functions by activating dioxygen (O 2) and
therefore allowing chemical energy-transfer for aerobic metabolism. The copper …

Abstract Zinc transporter 3 (ZnT3) is the sole mechanism responsible for concentrating zinc
ions within synaptic vesicles in a subset of the brain's glutamatergic neurons. This vesicular …

Zinc participation is essential for all physiological systems, including neural functioning,
where it participates in a myriad of cellular processes. Converging clinical, molecular, and …