Generation of vascular smooth muscle cells from induced pluripotent stem cells: methods, applications, and considerations

M Shen, T Quertermous, MP Fischbein… - Circulation research, 2021 - Am Heart Assoc
The developmental origin of vascular smooth muscle cells (VSMCs) has been increasingly
recognized as a major determinant for regional susceptibility or resistance to vascular …

Engineering Organ-on-a-Chip Systems for Vascular Diseases

A Shakeri, Y Wang, Y Zhao, S Landau… - … , and vascular biology, 2023 - Am Heart Assoc
Vascular diseases, such as atherosclerosis and thrombosis, are major causes of morbidity
and mortality worldwide. Traditional in vitro models for studying vascular diseases have …

Hierarchical vessel network-supported tumor model-on-a-chip constructed by induced spontaneous anastomosis

Y Zhou, Y Wu, R Paul, X Qin, Y Liu - ACS applied materials & …, 2023 - ACS Publications
The vascular system in living tissues is a highly organized system that consists of vessels
with various diameters for nutrient delivery and waste transport. In recent years, many vessel …

Genetic enhancement: an avenue to combat aging-related diseases

Y Cai, Z Ji, S Wang, W Zhang, J Qu, JCI Belmonte… - Life …, 2022 - academic.oup.com
Aging is a major risk factor for multiple diseases, including cardiovascular diseases,
neurodegenerative disorders, osteoarthritis, and cancer. It is accompanied by the …

Molecular and cellular mechanisms driving cardiovascular disease in Hutchinson-Gilford progeria syndrome: lessons learned from animal models

I Benedicto, B Dorado, V Andrés - Cells, 2021 - mdpi.com
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease that recapitulates
many symptoms of physiological aging and precipitates death. Patients develop severe …

Cellular reprogramming as a tool to model human aging in a dish

PR Pitrez, LM Monteiro, O Borgogno, X Nissan… - Nature …, 2024 - nature.com
The design of human model systems is highly relevant to unveil the underlying mechanisms
of aging and to provide insights on potential interventions to extend human health and life …

Vascular senescence in progeria: role of endothelial dysfunction

Q Xu, A Mojiri, L Boulahouache… - … Heart Journal Open, 2022 - academic.oup.com
Abstract Aims Hutchinson–Gilford progeria syndrome (HGPS) is a pre-mature aging disorder
caused by the mutation of the LMNA gene leading to an irreversibly farnesylated lamin A …

Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers replication stress and an aging-associated secretory signature

N Coll-Bonfill, U Mahajan, EV Shashkova, CJ Lin… - Geroscience, 2023 - Springer
Hutchinson-Gilford progeria syndrome is a premature aging disease caused by LMNA gene
mutation and the production of a truncated prelamin A protein “progerin” that elicits cellular …

Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg

G Farber, Y Dong, Q Wang, M Rathod, H Wang… - Nature …, 2024 - nature.com
Endothelial cells are a heterogeneous population with various organ-specific and conserved
functions that are critical to organ development, function, and regeneration. Here we report a …

Endothelial cell direct reprogramming: Past, present, and future

S Cho, P Aakash, S Lee, Y Yoon - Journal of Molecular and Cellular …, 2023 - Elsevier
Ischemic cardiovascular disease still remains as a leading cause of morbidity and mortality
despite various medical, surgical, and interventional therapy. As such, cell therapy has …