Generation of vascular smooth muscle cells from induced pluripotent stem cells: methods, applications, and considerations
The developmental origin of vascular smooth muscle cells (VSMCs) has been increasingly
recognized as a major determinant for regional susceptibility or resistance to vascular …
recognized as a major determinant for regional susceptibility or resistance to vascular …
Engineering Organ-on-a-Chip Systems for Vascular Diseases
Vascular diseases, such as atherosclerosis and thrombosis, are major causes of morbidity
and mortality worldwide. Traditional in vitro models for studying vascular diseases have …
and mortality worldwide. Traditional in vitro models for studying vascular diseases have …
Hierarchical vessel network-supported tumor model-on-a-chip constructed by induced spontaneous anastomosis
The vascular system in living tissues is a highly organized system that consists of vessels
with various diameters for nutrient delivery and waste transport. In recent years, many vessel …
with various diameters for nutrient delivery and waste transport. In recent years, many vessel …
Genetic enhancement: an avenue to combat aging-related diseases
Aging is a major risk factor for multiple diseases, including cardiovascular diseases,
neurodegenerative disorders, osteoarthritis, and cancer. It is accompanied by the …
neurodegenerative disorders, osteoarthritis, and cancer. It is accompanied by the …
Molecular and cellular mechanisms driving cardiovascular disease in Hutchinson-Gilford progeria syndrome: lessons learned from animal models
I Benedicto, B Dorado, V Andrés - Cells, 2021 - mdpi.com
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease that recapitulates
many symptoms of physiological aging and precipitates death. Patients develop severe …
many symptoms of physiological aging and precipitates death. Patients develop severe …
Cellular reprogramming as a tool to model human aging in a dish
PR Pitrez, LM Monteiro, O Borgogno, X Nissan… - Nature …, 2024 - nature.com
The design of human model systems is highly relevant to unveil the underlying mechanisms
of aging and to provide insights on potential interventions to extend human health and life …
of aging and to provide insights on potential interventions to extend human health and life …
Vascular senescence in progeria: role of endothelial dysfunction
Q Xu, A Mojiri, L Boulahouache… - … Heart Journal Open, 2022 - academic.oup.com
Abstract Aims Hutchinson–Gilford progeria syndrome (HGPS) is a pre-mature aging disorder
caused by the mutation of the LMNA gene leading to an irreversibly farnesylated lamin A …
caused by the mutation of the LMNA gene leading to an irreversibly farnesylated lamin A …
Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers replication stress and an aging-associated secretory signature
N Coll-Bonfill, U Mahajan, EV Shashkova, CJ Lin… - Geroscience, 2023 - Springer
Hutchinson-Gilford progeria syndrome is a premature aging disease caused by LMNA gene
mutation and the production of a truncated prelamin A protein “progerin” that elicits cellular …
mutation and the production of a truncated prelamin A protein “progerin” that elicits cellular …
Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg
Endothelial cells are a heterogeneous population with various organ-specific and conserved
functions that are critical to organ development, function, and regeneration. Here we report a …
functions that are critical to organ development, function, and regeneration. Here we report a …
Endothelial cell direct reprogramming: Past, present, and future
S Cho, P Aakash, S Lee, Y Yoon - Journal of Molecular and Cellular …, 2023 - Elsevier
Ischemic cardiovascular disease still remains as a leading cause of morbidity and mortality
despite various medical, surgical, and interventional therapy. As such, cell therapy has …
despite various medical, surgical, and interventional therapy. As such, cell therapy has …