[HTML][HTML] NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches
Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular
defense mechanisms as well as physiological functions, and intracellular signaling …
defense mechanisms as well as physiological functions, and intracellular signaling …
Health benefits of plant-derived sulfur compounds, glucosinolates, and organosulfur compounds
The broad spectrum of the mechanism of action of immune-boosting natural compounds as
well as the complex nature of the food matrices make researching the health benefits of …
well as the complex nature of the food matrices make researching the health benefits of …
NF-κβ: a potential target in the management of vascular complications of diabetes
SV Suryavanshi, YA Kulkarni - Frontiers in pharmacology, 2017 - frontiersin.org
Diabetes is a metabolic disorder affecting large percentage of population worldwide. NF-κβ
plays key role in pathogenesis of vascular complications of diabetes. Persistent …
plays key role in pathogenesis of vascular complications of diabetes. Persistent …
Mechanisms of diabetic complications
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …
required, but also for its major complications, affecting both small and large blood vessels …
Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets
S Dewanjee, S Das, AK Das, N Bhattacharjee… - European journal of …, 2018 - Elsevier
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …
Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes
AS Axelsson, E Tubbs, B Mecham, S Chacko… - Science translational …, 2017 - science.org
A potentially useful approach for drug discovery is to connect gene expression profiles of
disease-affected tissues (“disease signatures”) to drug signatures, but it remains to be …
disease-affected tissues (“disease signatures”) to drug signatures, but it remains to be …
Glucosinolates and isothiocyanates in health and disease
AT Dinkova-Kostova, RV Kostov - Trends in molecular medicine, 2012 - cell.com
Glucosinolates and isothiocyanates have both been objects of research for more than half a
century. Interest in these unique phytochemicals escalated following the discovery that …
century. Interest in these unique phytochemicals escalated following the discovery that …
[HTML][HTML] Oxidative stress and nerve damage: role in chemotherapy induced peripheral neuropathy
Peripheral neuropathy is a severe dose limiting toxicity associated with cancer
chemotherapy. Ever since it was identified, the clear pathological mechanisms underlying …
chemotherapy. Ever since it was identified, the clear pathological mechanisms underlying …
Neuroinflammation and oxidative stress in diabetic neuropathy: futuristic strategies based on these targets
In Diabetes, the chronic hyperglycemia and associated complications affecting peripheral
nerves are one of the most commonly occurring microvascular complications with an overall …
nerves are one of the most commonly occurring microvascular complications with an overall …
[HTML][HTML] Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
M Matzinger, K Fischhuber, EH Heiss - Biotechnology advances, 2018 - Elsevier
Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …