The bioinformatics toolbox for circRNA discovery and analysis

L Chen, C Wang, H Sun, J Wang, Y Liang… - Briefings in …, 2021 - academic.oup.com
Circular RNAs (circRNAs) are a unique class of RNA molecule identified more than 40 years
ago which are produced by a covalent linkage via back-splicing of linear RNA. Recent …

Updated review of advances in microRNAs and complex diseases: experimental results, databases, webservers and data fusion

L Huang, L Zhang, X Chen - Briefings in bioinformatics, 2022 - academic.oup.com
MicroRNAs (miRNAs) are gene regulators involved in the pathogenesis of complex
diseases such as cancers, and thus serve as potential diagnostic markers and therapeutic …

miRTarBase 2020: updates to the experimentally validated microRNA–target interaction database

HY Huang, YCD Lin, J Li, KY Huang… - Nucleic acids …, 2020 - academic.oup.com
MicroRNAs (miRNAs) are small non-coding RNAs (typically consisting of 18–25
nucleotides) that negatively control expression of target genes at the post-transcriptional …

HMDD v2. 0: a database for experimentally supported human microRNA and disease associations

Y Li, C Qiu, J Tu, B Geng, J Yang, T Jiang… - Nucleic acids …, 2014 - academic.oup.com
Abstract The Human microRNA Disease Database (HMDD; available via the Web site at
http://cmbi. bjmu. edu. cn/hmdd and http://202.38. 126.151/hmdd/tools/hmdd2. html) is a …

Interaction and cross-talk between non-coding RNAs

S Yamamura, M Imai-Sumida, Y Tanaka… - Cellular and molecular …, 2018 - Springer
Non-coding RNA (ncRNA) has been shown to regulate diverse cellular processes and
functions through controlling gene expression. Long non-coding RNAs (lncRNAs) act as a …

PolymiRTS Database 3.0: linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways

A Bhattacharya, JD Ziebarth, Y Cui - Nucleic acids research, 2014 - academic.oup.com
Poly morphisms in mi cro R NAs (miRNAs) and their t arget s ites (PolymiRTS) are known to
disrupt miRNA function, leading to the development of disease and variation in physiological …

Bioinformatic tools for microRNA dissection

MM Akhtar, L Micolucci, MS Islam, F Olivieri… - Nucleic acids …, 2016 - academic.oup.com
Recently, microRNAs (miRNAs) have emerged as important elements of gene regulatory
networks. MiRNAs are endogenous single-stranded non-coding RNAs (∼ 22-nt long) that …

The untranslated regions of mRNAs in cancer

SL Schuster, AC Hsieh - Trends in cancer, 2019 - cell.com
The 5′ and 3′ untranslated regions (UTRs) regulate crucial aspects of post-transcriptional
gene regulation that are necessary for the maintenance of cellular homeostasis. When these …

CAP-miRSeq: a comprehensive analysis pipeline for microRNA sequencing data

Z Sun, J Evans, A Bhagwate, S Middha, M Bockol… - BMC genomics, 2014 - Springer
Background miRNAs play a key role in normal physiology and various diseases. miRNA
profiling through next generation sequencing (miRNA-seq) has become the main platform …

OncomiRDB: a database for the experimentally verified oncogenic and tumor-suppressive microRNAs

D Wang, J Gu, T Wang, Z Ding - Bioinformatics, 2014 - academic.oup.com
MicroRNAs (miRNAs), a class of small regulatory RNAs, play important roles in cancer
initiation, progression and therapy. MiRNAs are found to regulate diverse cancer-related …