Platelets have long been recognized as key players in hemostasis and thrombosis;
however, growing evidence suggests that they are also significantly involved in cancer, the …

Cysteine thiols are among the most reactive functional groups in proteins, and their pairing
in disulfide linkages is a common post-translational modification in proteins entering the …

Studies have shown significantly increased thromboembolic events at high altitude. We
recently reported that transferrin could potentiate blood coagulation, but the underlying …

Recent evidence of distinct ITP pathophysiology has opened new exploratory avenues for
disease management. We will discuss the utility of investigations into these mechanisms of …

Platelet αIIbβ3 integrin and its ligands are essential for thrombosis and hemostasis, and play
key roles in myocardial infarction and stroke. Here we show that apolipoprotein A-IV (apoA …

Although platelets are critically involved in thrombosis and hemostasis, experimental and
clinical evidence indicate that platelets promote tumor progression and metastasis through a …

Redox-mediated signal transduction depends on the enzymatic production of second
messengers such as hydrogen peroxide, nitric oxide and hydrogen sulfite, as well as …

Platelets are small anucleated cell fragments that ensure the arrest of bleeding after a vessel
wall injury. They are also involved in non-hemostatic function such as development …

Platelet receptors are how platelets interact with their environment in order to function. They
enable signals to pass to the platelet interior and change functional aspects of the platelet …

Thrombopoietin (TPO), a hematopoietic growth factor produced predominantly by the liver, is
essential for thrombopoiesis. Prevailing theory posits that circulating TPO levels are …