The availability of the first molecular clone of the hepatitis C virus (HCV) genome allowed
the identification and biochemical characterization of two viral enzymes that are targets for …

Abstract Nonconjugated hydrocarbons, like bicyclo [1.1. 1] pentane, bicyclo [2.2. 2] octane,
triptycene, and cubane are a unique class of rigid linkers. Due to their similarity in size and …

Great progress has been made over the past years in elucidating the structure and function
of the hepatitis C virus (HCV) proteins, most of which are now actively being pursued as …

The expression of pattern-recognition receptors (PRRs) by immune and tissue cells provides
the host with the ability to detect and respond to infection by viruses and other …

The nonstructural 5A (NS5A) protein is a target for drug development against hepatitis C
virus (HCV). Interestingly, the NS5A inhibitor daclatasvir (BMS-790052) caused a decrease …

In the 15 years since the discovery of hepatitis C virus (HCV), much has been learned about
its role as a major causative agent of human liver disease and its ability to persist in the face …

Since the discovery of the hepatitis C virus over 15 years ago, scientists have raced to
develop diagnostics, study the virus and find new therapies. Yet virtually every attempt to …

Liver cancer is among the leading global healthcare issues associated with high morbidity
and mortality. Liver cancer consists of hepatocellular carcinoma (HCC), cholangiocarcinoma …

It is estimated that viral infections contribute to 15–20% of all human cancers. As obligatory
intracellular parasites, viruses encode proteins that reprogram host cellular signaling …

Persistent infection with the hepatitis C virus (HCV) is a major risk factor for the development
of liver cirrhosis and hepatocellular carcinoma. With an estimated about 3% of the world …