Enhancers as non-coding RNA transcription units: recent insights and future perspectives
Networks of regulatory enhancers dictate distinct cell identities and cellular responses to
diverse signals by instructing precise spatiotemporal patterns of gene expression. However …
diverse signals by instructing precise spatiotemporal patterns of gene expression. However …
Implications of enhancer transcription and eRNAs in cancer
Despite extensive progress in developing anticancer therapies, therapy resistance remains
a major challenge that promotes disease relapse. The changes that lead to therapy …
a major challenge that promotes disease relapse. The changes that lead to therapy …
A comparison of experimental assays and analytical methods for genome-wide identification of active enhancers
Mounting evidence supports the idea that transcriptional patterns serve as more specific
identifiers of active enhancers than histone marks; however, the optimal strategy to identify …
identifiers of active enhancers than histone marks; however, the optimal strategy to identify …
DNA methylation controls metastasis-suppressive 14q32-encoded miRNAs
Expression of 14q32-encoded miRNAs is a favorable prognostic factor in patients with
metastatic cancer. In this study, we used genomic inhibition of DNA methylation through …
metastatic cancer. In this study, we used genomic inhibition of DNA methylation through …
Transcriptional and post-transcriptional regulation of the ionizing radiation response by ATM and p53
I Venkata Narayanan, MT Paulsen, K Bedi, N Berg… - Scientific Reports, 2017 - nature.com
In response to ionizing radiation (IR), cells activate a DNA damage response (DDR)
pathway to re-program gene expression. Previous studies using total cellular RNA analyses …
pathway to re-program gene expression. Previous studies using total cellular RNA analyses …
Intracellular RNA sensing in mammalian cells: role in stress response and cancer therapies
NN Khodarev - International review of cell and molecular biology, 2019 - Elsevier
DNA damage has been considered the primary action of ionizing radiation (IR) in normal
and tumor cells resulting in cell autonomous death. However, recent findings have …
and tumor cells resulting in cell autonomous death. However, recent findings have …
Enhancer-derived RNA: a primer
F Liu - Genomics, Proteomics and Bioinformatics, 2017 - academic.oup.com
Enhancer-derived RNAs (eRNAs) are a group of RNAs transcribed by RNA polymerase II
from the domain of transcription enhancers, a major type of cis-regulatory elements in the …
from the domain of transcription enhancers, a major type of cis-regulatory elements in the …
Enhanced frequency of transcription pre-initiation complexes assembly after exposure to UV irradiation results in increased repair activity and reduced probabilities for …
A Liakos, AC Synacheri… - Nucleic Acids …, 2023 - academic.oup.com
In addition to being essential for gene expression, transcription is crucial for the
maintenance of genome integrity. Here, we undertook a systematic approach, to monitor the …
maintenance of genome integrity. Here, we undertook a systematic approach, to monitor the …
Continuous transcription initiation guarantees robust repair of all transcribed genes and regulatory regions
A Liakos, D Konstantopoulos, MD Lavigne… - Nature …, 2020 - nature.com
Inhibition of transcription caused by DNA damage-impaired RNA polymerase II (Pol II)
elongation conceals a local increase in de novo transcription, slowly progressing from …
elongation conceals a local increase in de novo transcription, slowly progressing from …
Toward a comprehensive catalog of regulatory elements
Regulatory elements are the genomic regions that interact with transcription factors to
control cell-type-specific gene expression in different cellular environments. A precise and …
control cell-type-specific gene expression in different cellular environments. A precise and …