In the evolutionary battle between viruses and their hosts, viruses have armed themselves
with weapons to defeat the host's attacks on infected cells. Various proteins encoded in the …

A great deal has been learned about the molecular biology of viruses. However, much less
is known at the molecular level about how viruses usurp the infected cell and how they …

A phase I clinical trial was conducted to determine the clinical safety of Telomelysin, a
human telomerase reverse transcriptase (hTERT) promoter driven modified oncolytic …

Although genetically engineered adenoviruses hold promise for the treatment of cancer,
clinical trial reports have utilized intratumoral injection to date. To determine the feasibility of …

Publisher Summary This chapter presents an overview of T cell recognition and function.
Complex organisms coevolved with a wide variety of microorganisms—viruses, bacteria …

Cytotoxic T cells use Fas (CD95), a member of the tumor necrosis factor (TNF) receptor
superfamily, to eliminate virus-infected cells by activation of the apoptotic pathway for cell …

In the 1990s, adenovirus became one of the first virus types to be genetically engineered to
selectively destroy cancer cells. In the intervening years, the field of “oncolytic viruses” has …

For decades cell biologists have relied on viruses to facilitate the study of complex cellular
function. More recently, the tragedy of the AIDS epidemic has focused considerable human …

The role of exocytosis of major histocompatibility complex (MHC) class I molecules in the
presentation of antigens to mouse cytotoxic T lymphocytes (CTLs) was examined by use of a …

Adenovirus is a human pathogen that infects mainly respiratory and gastrointestinal
epithelia. While the pathology caused by this virus is generally not life threatening in …