Toxoplasma Effectors Targeting Host Signaling and Transcription

MA Hakimi, P Olias, LD Sibley - Clinical microbiology reviews, 2017 - Am Soc Microbiol
Early electron microscopy studies revealed the elaborate cellular features that define the
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …

Modulation of innate immunity by Toxoplasma gondii virulence effectors

CA Hunter, LD Sibley - Nature Reviews Microbiology, 2012 - nature.com
Toxoplasma gondii is a common parasite of animals and humans and can cause serious
opportunistic infections. However, the majority of infections are asymptomatic, possibly …

Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9

B Shen, KM Brown, TD Lee, LD Sibley - MBio, 2014 - Am Soc Microbiol
Toxoplasma gondii has become a model for studying the phylum Apicomplexa, in part due
to the availability of excellent genetic tools. Although reverse genetic tools are available in a …

Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity

EC Andersen, JP Gerke, JA Shapiro, JR Crissman… - Nature …, 2012 - nature.com
The nematode Caenorhabditis elegans is central to research in molecular, cell and
developmental biology, but nearly all of this research has been conducted on a single strain …

Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages

C Su, A Khan, P Zhou, D Majumdar… - Proceedings of the …, 2012 - National Acad Sciences
Marked phenotypic variation characterizes isolates of Toxoplasma gondii, a ubiquitous
zoonotic parasite that serves as an important experimental model for studying apicomplexan …

Neurons are the Primary Target Cell for the Brain-Tropic Intracellular Parasite Toxoplasma gondii

CM Cabral, S Tuladhar, HK Dietrich, E Nguyen… - PLoS …, 2016 - journals.plos.org
Toxoplasma gondii, a common brain-tropic parasite, is capable of infecting most nucleated
cells, including astrocytes and neurons, in vitro. Yet, in vivo, Toxoplasma is primarily found in …

Genetic analyses of atypical Toxoplasma gondii strains reveal a fourth clonal lineage in North America

A Khan, JP Dubey, C Su, JW Ajioka… - International journal for …, 2011 - Elsevier
Toxoplasma gondii is a widespread parasite of animals that causes zoonotic infections in
humans. Previous studies have revealed a strongly clonal population structure in North …

Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence

SJ Fentress, MS Behnke, IR Dunay, M Mashayekhi… - Cell host & …, 2010 - cell.com
Macrophages are specialized to detect and destroy intracellular microbes and yet a number
of pathogens have evolved to exploit this hostile niche. Here we demonstrate that the …

Genetic diversity of Toxoplasma gondii in animals and humans

LD Sibley, A Khan, JW Ajioka… - … Transactions of the …, 2009 - royalsocietypublishing.org
Toxoplasma gondii is one of the most widespread parasites of domestic, wild, and
companion animals, and it also commonly infects humans. Toxoplasma gondii has a …

Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases

MS Behnke, A Khan, JC Wootton… - Proceedings of the …, 2011 - National Acad Sciences
The population structure of Toxoplasma gondii includes three highly prevalent clonal
lineages referred to as types I, II, and III, which differ greatly in virulence in the mouse model …