Many psychiatric disorders, despite their specific characteristics, share deficits in the
cognitive domain including executive functions, emotional control and memory. However …

In the brain, neuronal gene expression is dynamically changed in response to neuronal
activity. In particular, the expression of immediate-early genes (IEGs) such as egr-1, c-fos …

Microplastics (MPs) pollution has become a serious environmental issue worldwide, but its
potential effects on health remain unknown. The administration of polystyrene MPs (PS …

Pavlovian fear conditioning is a particularly useful behavioral paradigm for exploring the
molecular mechanisms of learning and memory because a well-defined response to a …

The last 10 years have witnessed a surge of interest for the mechanisms underlying the
acquisition and extinction of classically conditioned fear responses. In part, this results from …

Over the course of natural history, countless animal species have evolved adaptive
behavioral systems to cope with dangerous situations and promote survival. Emotional …

Many proteins have been implicated in synaptic and experience-dependent plasticity.
However, few demonstrate the exquisite regulation of expression and breadth of functional …

The activity-regulated cytoskeletal (Arc) gene encodes a protein that is critical for memory
consolidation. Arc is one of the most tightly regulated molecules known: neuronal activity …

The immediate early gene Arc is emerging as a versatile, finely tuned system capable of
coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing …

Summary The Arc/Arg3. 1 gene product is rapidly upregulated by strong synaptic activity and
critically contributes to weakening synapses by promoting AMPA-R endocytosis. However …