T cell lineages are defined by specialized functions and differential expression of surface
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …

Immunotherapies targeting conventional T cells have revolutionized systemic treatment for
many cancers, yet only a subset of patients benefit from these approaches. A better …

Tissue repair processes maintain proper organ function following mechanical or infection-
related damage. In addition to antibacterial properties, mucosal associated invariant T …

The mechanisms underlying human natural killer (NK) cell phenotypic and functional
heterogeneity are unknown. Here, we describe the emergence of diverse subsets of human …

Abstract γδ T cells are situated at barrier sites and guard the body from infection and
damage. However, little is known about their roles outside of host defense in nonbarrier …

γδ T cells, αβ T cells, and B cells are present together in all but the most primitive
vertebrates, suggesting that each population contributes to host immune competence …

IL-17A–producing γδ T cells in mice consist primarily of Vγ6+ tissue-resident cells and Vγ4+
circulating cells. How these γδ T cell subsets are regulated during homeostasis and cancer …

Studies on the biology of mucosal-associated invariant T cells (MAIT cells) in mice have
been hampered by a lack of specific reagents. Using MR1-antigen (Ag) tetramers that …

Abstract γδ T cells have several innate cell-like features that allow their early activation
following recognition of conserved stress-induced ligands. Here we review recent …

Invariant natural killer T cells (i NKT cells) are lipid-sensing innate T cells that are restricted
by the antigen-presenting molecule CD1d and express the transcription factor PLZF. i NKT …