Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in
the treatment of various diseases. However, owing to the dynamic nature of the immune …

Asthma is a complex respiratory disorder characterized by marked heterogeneity in
individual patient disease triggers and response to therapy. Several asthma phenotypes …

There are significant numbers of nutrient sensing G protein-coupled receptors (GPCRs) that
can be found in cells of the immune system and in tissues that are involved in metabolic …

Background Allergic asthma is characterized by airway hyperreactivity (AHR) and
inflammation driven by aberrant TH 2 responses. Type 2 innate lymphoid cells (ILC2s) are a …

Background In placebo-controlled trials, reslizumab, an anti-IL-5 monoclonal antibody,
significantly reduced asthma exacerbations and improved lung function and asthma control …

We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma. Human
bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral …

Chromosome 17q21 contains a cluster of genes including ORMDL3 and GSDMB, which
have been highly linked to asthma in genome-wide association studies. ORMDL3 is …

Abstract Interleukin (IL)-1R3 is the co-receptor in three signaling pathways that involve six
cytokines of the IL-1 family (IL-1α, IL-1β, IL-33, IL-36α, IL-36β and IL-36γ). In many diseases …

Background Current biologic therapies target allergic, eosinophilic or type 2 inflammation
phenotypic asthma. However, frequency and degree of overlap among these subtypes is …

Plants are regarded as a valuable and inexpensive source of new drug development, and a
variety of plant compounds are now being used in clinical trials to treat a variety of ailments …