Immune cell functions are regulated by co-inhibitory and co-stimulatory receptors. The first
two generations of cancer immunotherapy agents consist primarily of antagonist antibodies …

NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis
and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn …

Genome-wide association studies (GWAS) have identified thousands of genetic variants
associated with human complex traits. However, the genes or functional DNA elements …

Rationale: Emerging evidence demonstrates that insufficient migration and invasion of
trophoblasts play critical roles in the pathogenesis of recurrent spontaneous abortion (RSA) …

This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …

The transcription factor NF-κB has been the focus of intense investigation for nearly two
decades. Over this period, considerable progress has been made in determining the …

Fish is considered to be an important model in comparative immunology studies because it
is a representative population of lower vertebrates serving as an essential link to early …

High mobility group box 1 (HMGB1) protein, originally described as a DNA-binding protein
that stabilizes nucleosomes and facilitates transcription, can also be released extracellularly …

▪ Abstract Several members of the tumor necrosis factor receptor (TNFR) family function after
initial T cell activation to sustain T cell responses. This review focuses on CD27, 4-1BB …

The transcription factor NF-κB (nuclear factor kappa enhancer binding protein) controls
many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates …