Receptor type protein tyrosine phosphatases (RPTPs)–roles in signal transduction and human disease

Y Xu, GJ Fisher - Journal of cell communication and signaling, 2012 - Springer
Protein tyrosine phosphorylation is a fundamental regulatory mechanism controlling cell
proliferation, differentiation, communication, and adhesion. Disruption of this key regulatory …

Mutations in PTPRQ are a cause of autosomal-recessive nonsyndromic hearing impairment DFNB84 and associated with vestibular dysfunction

M Schraders, J Oostrik, PLM Huygen, TM Strom… - The American Journal of …, 2010 - cell.com
We identified overlapping homozygous regions within the DFNB84 locus in a
nonconsanguineous Dutch family and a consanguineous Moroccan family with …

Disrupting PTPRJ transmembrane-mediated oligomerization counteracts oncogenic receptor tyrosine kinase FLT3 ITD

M Schwarz, S Rizzo, WE Paz, A Kresinsky… - Frontiers in …, 2022 - frontiersin.org
The receptor protein tyrosine phosphatase (RPTP) PTPRJ (also known as DEP-1) has been
identified as a negative regulator of the receptor tyrosine kinase FLT3 signalling in vitro. The …

Disrupting the transmembrane domain–mediated oligomerization of protein tyrosine phosphatase receptor J inhibits EGFR-driven cancer cell phenotypes

E Bloch, EL Sikorski, D Pontoriero, EK Day… - Journal of Biological …, 2019 - ASBMB
Receptor protein tyrosine phosphatases (RPTPs) play critical regulatory roles in mammalian
signal transduction. However, the structural basis for the regulation of their catalytic activity is …

Discovery of PTPRJ Agonist Peptides That Effectively Inhibit in Vitro Cancer Cell Proliferation and Tube Formation

F Ortuso, F Paduano, A Carotenuto… - ACS chemical …, 2013 - ACS Publications
PTPRJ is a receptor protein tyrosine phosphatase involved in both physiological and
oncogenic pathways. We previously reported that its expression is strongly reduced in the …

Isolation and functional characterization of peptide agonists of PTPRJ, a tyrosine phosphatase receptor endowed with tumor suppressor activity

F Paduano, F Ortuso, P Campiglia, C Raso… - ACS chemical …, 2012 - ACS Publications
PTPRJ is a receptor-type protein tyrosine phosphatase whose expression is strongly
reduced in the majority of investigated cancer cell lines and tumor specimens. PTPRJ …

High-fat diet alters N-glycosylation of PTPRJ in murine liver

J Ulke, C Schwedler, J Krüger, V Stein… - The Journal of …, 2024 - Elsevier
Protein tyrosine phosphatases (PTPs) regulate multiple signaling pathways. Disruption of
tyrosine phosphorylation through imbalanced action between protein tyrosine kinases …

Protein tyrosine phosphatase PTPRJ is negatively regulated by microRNA‐328

F Paduano, V Dattilo, D Narciso, A Bilotta… - The FEBS …, 2013 - Wiley Online Library
Expression of PTPRJ, which is a ubiquitous receptor‐type protein tyrosine phosphatase, is
significantly reduced in a vast majority of human epithelial cancers and cancer cell lines (ie …

Receptor tyrosine kinase inhibitors and cytotoxic drugs affect pleural mesothelioma cell proliferation: insight into EGFR and ERK1/2 as antitumor targets

F Barbieri, R Würth, RE Favoni, A Pattarozzi… - Biochemical …, 2011 - Elsevier
Malignant pleural mesothelioma (MPM) is an aggressive chemotherapy-resistant cancer. Up-
regulation of epidermal growth factor receptor (EGFR) plays an important role in MPM …

Role of PTPRJ genotype in papillary thyroid carcinoma risk

R Iuliano, D Palmieri, H He, A Iervolino… - Endocrine-related …, 2010 - erc.bioscientifica.com
The strong genetic predisposition to papillary thyroid carcinoma (PTC) might be due to a
combination of low-penetrance susceptibility variants. Thus, the research into gene variants …