Community detection and stochastic block models: recent developments

E Abbe - Journal of Machine Learning Research, 2018 - jmlr.org
The stochastic block model (SBM) is a random graph model with planted clusters. It is widely
employed as a canonical model to study clustering and community detection, and provides …

Rationally engineered nucleic acid architectures for biosensing applications

M Xiao, W Lai, T Man, B Chang, L Li… - Chemical …, 2019 - ACS Publications
Development of biosensing platforms plays a key role in research settings for identification
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …

Protein‐protein interaction detection: methods and analysis

VS Rao, K Srinivas, GN Sujini… - International journal of …, 2014 - Wiley Online Library
Protein‐protein interaction plays key role in predicting the protein function of target protein
and drug ability of molecules. The majority of genes and proteins realize resulting …

AF2Complex predicts direct physical interactions in multimeric proteins with deep learning

M Gao, D Nakajima An, JM Parks, J Skolnick - Nature communications, 2022 - nature.com
Accurate descriptions of protein-protein interactions are essential for understanding
biological systems. Remarkably accurate atomic structures have been recently computed for …

[HTML][HTML] MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes

SAA Rehman, YA Kristariyanto, SY Choi, PJ Nkosi… - Molecular cell, 2016 - cell.com
Deubiquitinating enzymes (DUBs) remove ubiquitin (Ub) from Ub-conjugated substrates to
regulate the functional outcome of ubiquitylation. Here we report the discovery of a new …

[HTML][HTML] A large-scale evaluation of computational protein function prediction

P Radivojac, WT Clark, TR Oron, AM Schnoes… - Nature …, 2013 - nature.com
Automated annotation of protein function is challenging. As the number of sequenced
genomes rapidly grows, the overwhelming majority of protein products can only be …

Community detection in general stochastic block models: Fundamental limits and efficient algorithms for recovery

E Abbe, C Sandon - 2015 IEEE 56th Annual Symposium on …, 2015 - ieeexplore.ieee.org
New phase transition phenomena have recently been discovered for the stochastic block
model, for the special case of two non-overlapping symmetric communities. This gives raise …

The role of protein loops and linkers in conformational dynamics and allostery

E Papaleo, G Saladino, M Lambrughi… - Chemical …, 2016 - ACS Publications
Proteins are dynamic entities that undergo a plethora of conformational changes that may
take place on a wide range of time scales. These changes can be as small as the rotation of …

Learning spatial structures of proteins improves protein–protein interaction prediction

B Song, X Luo, X Luo, Y Liu, Z Niu… - Briefings in …, 2022 - academic.oup.com
Spatial structures of proteins are closely related to protein functions. Integrating protein
structures improves the performance of protein–protein interaction (PPI) prediction …

Structure, dynamics, assembly, and evolution of protein complexes

JA Marsh, SA Teichmann - Annual review of biochemistry, 2015 - annualreviews.org
The assembly of individual proteins into functional complexes is fundamental to nearly all
biological processes. In recent decades, many thousands of homomeric and heteromeric …