Anaplastic lymphoma kinase (ALK) alterations (activating mutations, amplifications, and
fusions/rearrangements) occur in~ 3.3% of cancers. ALK fusions/rearrangements are …

Spitz neoplasms continue to be a diagnostic challenge for dermatopathologists and are
defined by distinctive morphological and genetic features. With the recent advancements in …

Identification of driver genes contributes to the understanding of cancer etiology and is
imperative for the development of individualized therapies. Gene amplification is a major …

A number of oncogenic driver mutations have been identified in melanocytic nevi and
melanoma, but translocations also play a role in tumorigenesis and provide potential …

Anaplastic lymphoma kinase (Alk) and leucocyte tyrosine kinase (Ltk) were identified as
“orphan” receptor tyrosine kinases (RTKs) with oncogenic potential. Recently ALKAL1 and …

Spitz nevi are indolent melanocytic tumors arising preferentially during and after childhood.
Over the last decades, recurrent oncogenic drivers, sparsely detected in melanoma, were …

Recent advances in next generation sequencing (NGS) have allowed for efficient whole
transcriptome sequencing, leading to the identification of important kinase fusions as the …

Simple Summary The management of unresectable and metastatic cutaneous melanoma
has substantially improved with the introduction of molecular targeted therapy (BRAF and …

The dramatic recent advances in therapy of melanoma require a more personalized and
precise diagnostic approach to aid in clinical decisions. Tissue-based biomarkers in …

Melanoma is an aggressive neoplasia issued from the malignant transformation of
melanocytes, the pigment-generating cells of the skin. It is responsible for about 75% of …