The aim of this critical review is to provide a broad but digestible overview of
mechanochemical synthesis, ie reactions conducted by grinding solid reactants together …

Processing-induced transformations (PITs) during pharmaceutical manufacturing are well
known but difficult to predict and often difficult to control. This review of the concepts of …

" Polymorphism in the Pharmaceutical Industry-Solid Form and Drug Development"
highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus …

Amorphous solids are conventionally formed by supercooling liquids or by concentrating
noncrystallizing solutes (spray-drying and freeze-drying). However, a lot of pharmaceutical …

This paper presents an overview of recent advances in understanding the role of the
amorphous state in the physical and chemical transformations of pharmaceutical materials …

Precise design of processes involving the use of benign and green solvents such as
supercritical carbon dioxide (SC CO 2) in the pharmaceutical industries requires …

Purpose The purpose of this work was to investigate the mechanisms of cocrystal formation
during cogrinding and storage of solid reactants, and to establish the effects of water by …

The effect of cryogenic grinding on five crystal forms of indomethacin (IMC) was investigated
with particular interest in the formation of amorphous phase. Powder X‐ray diffraction …

Milling is a usual process used in the course of drug formulation, which however may
change the physical nature of the end product. The diversity of the transformations of organic …

Purpose. To establish if FT-Raman Spectroscopy can be used to quantitate the degree of
crystallinity in a model compound. Methods. Mixtures containing different proportions of …