Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

Fatty liver accumulation results from an imbalance between lipid deposition and removal,
driven by the hepatic synthesis of triglycerides and de novo lipogenesis. The habitual diet …

Haemochromatosis is now known to be an iron-storage disease with genetic heterogeneity
but with a final common metabolic pathway resulting in inappropriately low production of the …

Hereditary iron overload includes several disorders characterized by iron accumulation in
tissues, organs, or even single cells or subcellular compartments. They are determined by …

The susceptibility to developing alcohol dependence and significant alcohol-related liver
injury is determined by a number of constitutional, environmental and genetic factors …

The discovery of hepcidin in 2000 and the subsequent unprecedented explosion of research
and discoveries in the iron field have dramatically changed our understanding of human …

After more than 10 years of accumulated efforts, genome-wide association studies (GWAS)
have led to many findings, most of which have been deposited into the GWAS Catalog …

The hemochromatosis gene HFE was discovered in 1996, more than a century after clinical
and pathologic manifestations of hemochromatosis were reported. Linked to the major …

Body iron has a very close relationship with the liver. Physiologically, the liver synthesizes
transferrin, in charge of blood iron transport; ceruloplasmin, acting through its ferroxidase …

Dietary iron absorption and systemic iron traffic are tightly controlled by hepcidin, a liver-
derived peptide hormone. Hepcidin inhibits iron entry into plasma by binding to and …