In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

Protein modifications provide cells with exquisite temporal and spatial control of protein
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …

Recently, many of the enzymes responsible for the addition and removal of ubiquitin from
the histones H2A and H2B have been identified and characterized. From these studies, it …

Regulation of gene transcription is vitally important for the maintenance of normal cellular
homeostasis. Failure to correctly regulate gene expression, or to deal with problems that …

The Ccr4–Not complex is a unique, essential and conserved multi-subunit complex that acts
at the level of many different cellular functions to regulate gene expression. Two enzymatic …

Summary Arabidopsis hexokinase1 (HXK1) is a glucose sensor that integrates nutrient and
hormone signals to govern gene expression and plant growth in response to environmental …

Principles of intracellular protein synthesis and protein degradation remain to be among the
most challenging questions of modern cell biology. Proteolysis plays an important role in …

A comprehensive mapping of interactions among Epstein–Barr virus (EBV) proteins and
interactions of EBV proteins with human proteins should provide specific hypotheses and a …

There is increasing evidence that longevity and stress resistance are connected, but the
mechanism is unclear. We report that mitochondria are regulated in response to oxidative …

Double-stranded RNA (dsRNA) fragments are readily internalized and processed by
Drosophila S2 cells, making these cells a widely used tool for the analysis of gene function …