Proteins constitute a key class of molecular components that perform essential biochemical
reactions in living cells. Whether the aim is to extensively characterize a given protein or to …

Mass-spectrometry-based proteomics is continuing to make major contributions to the
discovery of fundamental biological processes and, more recently, has also developed into …

Missing values weaken the power of label-free quantitative proteomic experiments to
uncover true quantitative differences between biological samples or experimental …

We present a data-independent acquisition mass spectrometry method, ultradefinition (UD)
MSE. This approach utilizes ion mobility drift time-specific collision-energy profiles to …

Integrative multi-omics analyses can empower more effective investigation and complete
understanding of complex biological systems. Despite recent advances in a range of omics …

To design a robust quantitative proteomics study, an understanding of both the inherent
heterogeneity of the biological samples being studied as well as the technical variability of …

Human plasma is one of the most widely used tissues in clinical analysis, and plasma-based
biomarkers are used for monitoring patient health status and/or response to medical …

Mass-spectrometry based omics technologies–namely proteomics, metabolomics and
lipidomics–have enabled the molecular level systems biology investigation of organisms in …

Label-free quantitation by data independent methods (for instance MSE) is growing in
popularity due to the high technical reproducibility of mass spectrometry analysis. The recent …

The majority of Mycobacterium tuberculosis (Mtb) infections are clinically latent,
characterized by drug tolerance and little or no bacterial replication. Low oxygen tension is a …